ID   SMG8_DROAN              Reviewed;         939 AA.
AC   B3MJV4;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GF14070;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; CH902620; EDV32409.1; -; Genomic_DNA.
DR   RefSeq; XP_001963188.1; XM_001963152.2.
DR   AlphaFoldDB; B3MJV4; -.
DR   SMR; B3MJV4; -.
DR   STRING; 7217.FBpp0117262; -.
DR   EnsemblMetazoa; FBtr0118770; FBpp0117262; FBgn0091097.
DR   GeneID; 6496898; -.
DR   KEGG; dan:6496898; -.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   InParanoid; B3MJV4; -.
DR   OMA; HCTVKDS; -.
DR   OrthoDB; 645776at2759; -.
DR   PhylomeDB; B3MJV4; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..939
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378172"
FT   REGION          561..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..588
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   939 AA;  106741 MW;  EB8874A011599699 CRC64;
     MKDYYTWTYP DVPENVAQEL LQLENSMVVV GIVGRSKCER ANKMQAFGMS PPMEHTPADG
     QVQCYYKRGT SCIFLHFETT YDEPILHRMI EDSMADHQNA FDFDHFYEQM RSRFVRMMLL
     ALHTCHIIVY VETGPTFDPT LVTVFQLLKF SREQHLKQFL PQMLRDTPAA KLGEKSRLCA
     PRILFLFENF PSDELKTREN VSAYEFQTED NIYEMLRHHH IFTNSSPSSL VALPNNKQFV
     YFNAHEELHP DYLLKAIDCL NKTMFKPDMR EEEEDLEILE LAPFEGFCKP FGPPGERDVE
     AQQYKRQHTA WHFLQRHIQD ALHGCFDEGS FKQLPHLGQF QLLSFPEWQG CMDTLTQLLV
     ENAKDTNFET NNEEYKNFLL NFEDSLNYEK KFWAHLCELG LKKGISSYKS SAPANYGSAT
     HRKLLAEATI AFEEEGRGPP AQAALARMAA ICLKHWQDGR QQCEKLSLRS QPCTLPKDVP
     HDKHNSGVIH ISSCNCGRTQ GRREDPFNLR QANYDFYELI AQICNLCVKV KQYQFPIFEP
     SVSDYRAAAF DAAFPMLNTG KICTPQGEDE NEDGETEEAD EDTEEKEQAE GDNCSQQLSP
     TFGSDLNMSI AGFGASLNES QESSEQLSGS EHESPNSGTS SADTENELVL QIKEPARKES
     TPTGGFSTST TEYLPGLVHT VSDFGLLPLF PSWSLACVGP SSIYSHNTGL QEHFQSGFLS
     GANFLLPWDV LLRLVHANKH HQQHHHNMHL QQHPGKKQQR WKKQGDRLSI KIFVGMEYEC
     SRGHRFMMCA PDRVLRGGAD IERDTCNKVV HSNMPLYYPC PCRSQSNYLA QLMRIHVVTP
     KAPVNIIVDP KVCVGKYTFT LGTIIPPRLS QSAYWILRLP FVYQGDNVMI APPEKLDPDN
     PMAGGYLLPG MFGVAETDAN MDLSNPSRMG STAGTFIRI