ID   SMG8_DROER              Reviewed;         949 AA.
AC   B3N538;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GG10361;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; CH954177; EDV58983.1; -; Genomic_DNA.
DR   RefSeq; XP_001969924.1; XM_001969888.2.
DR   AlphaFoldDB; B3N538; -.
DR   STRING; 7220.FBpp0128907; -.
DR   EnsemblMetazoa; FBtr0130415; FBpp0128907; FBgn0102670.
DR   GeneID; 6542675; -.
DR   KEGG; der:6542675; -.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   OMA; HCTVKDS; -.
DR   OrthoDB; 645776at2759; -.
DR   PhylomeDB; B3N538; -.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay.
FT   CHAIN           1..949
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378173"
FT   REGION          564..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          624..652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          748..768
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        586..607
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        748..765
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   949 AA;  107709 MW;  9284ADCE32C6B8C0 CRC64;
     MMKDYYTWTY PDIPEDVAQK LQQLKNSLVV VGIVGRSKCD QANKMQAFGM EPPIEHTAKD
     GQVQCYYKPG TSSLLLHFET TYDEAILGQM IDVCMEDVDT PFDFDSFYER MRCRFVRMML
     LALHACHIVV YVETGPTFDP TLVTVFQLLK FAREQHLMQF LPQMLRETPA ARMSEKTRLC
     APRILFLFEN FPRDEPKTRE CVSAYEFQTE DCIYELLRHH TIVTNSSSTS LVALPNNKQF
     VFFNAHEQLH EDKLLKAIEC LNQAMYKPDA KEEEEDLEIL ELAPFDGFVK PYNLPVDEKE
     LEKQQYKKDH TVWHFLQRHV QDALLGCFDE GSFKQHSQHG QFQLLNIQEW HDYMATLHKL
     LVENAKDPNH ETSNEEYKLF LKCFDESLNY EKKFWTHLCE LGLKKGIAAY KNAAPANYGS
     ATHRQLLADA TVAFEEEGRG PQAKAALAKL AAICQKYWQD GRQQCEQLSL RSHPCTLPKN
     LPHEKHNSAV IHISSCNCGR TQGRREDPFS MRQANYEFYE HIAQMCNLCV KVKHYKFPVF
     EPSVSDYRAA AFEAAFPLLH TAKSGARQGE EGDDEPEDEV VQEQQQPVEE QRQNTASNGC
     SQPLSPTFGS DLNMSIAGFG ASLNESQASS EQLSNSEQNT SSSGTSSADT ENELVVELQE
     PAKKETREDA GPADALPTST TEYLPGLVHT VSNFGLLPLF PSWSLACVGP SSIYSHNTGL
     QEHFQSGFLS GANFLLPWDV QLRLVHAPKQ QHHTHHQQQH PGKKQQRWKK QGDRLSLKIF
     VGMEYECSRG HRFMMCAPDR VLRGGADIER DTCSKVVHNN MPLYYPCPCR SQTSYLAQLM
     RIHVVTPKAP VNIIVDPKVC VGKEKYTFTL GSIVPPRLSQ SAYWIIRLPY IYQGDDVIIA
     PPEKLEPDDP LAGGYLLPGM FGVAETDATQ DLNEPGRMGA SAAEDFTRI