ID   SMG8_DROGR              Reviewed;         945 AA.
AC   B4JE52;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GH11308;
OS   Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Hawaiian Drosophila.
OX   NCBI_TaxID=7222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15287-2541.00;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; CH916368; EDW03572.1; -; Genomic_DNA.
DR   RefSeq; XP_001988705.1; XM_001988669.1.
DR   AlphaFoldDB; B4JE52; -.
DR   STRING; 7222.FBpp0145214; -.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   InParanoid; B4JE52; -.
DR   OMA; HCTVKDS; -.
DR   PhylomeDB; B4JE52; -.
DR   Proteomes; UP000001070; Unassembled WGS sequence.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..945
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378174"
FT   REGION          563..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..660
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   945 AA;  107543 MW;  6D82C0D07A83CB27 CRC64;
     MSFRKYYSWK YPDVPEDVAP LLLELKNSLV VVGVVGRSKC SLANKMSVFG MQPEETHEPA
     NGQIMCYYKP GTSTLLLHFE STHDEVVLGQ KLLEQTSIDF DHFYGNMRSQ FVRMMLLALH
     TCHIVVYVET GQTFDPALVT ICQLLKYVRE QHLLEFLPQL LRETSAGNLL GDRARLCTPR
     ILFIFENYPA DVEKTREFIS THEFQTEDKI YELFRQYNIV MQSASNSLLA LPNNKQFVFY
     NANEILRPDR LLLAIDALNA TMYKQDVKEE EEDLEIIALA PFEGFVKPFG DAYTVRKSDE
     QLYRESHTVW HFLQRHVQDA LEGCFDEGSF KQLSQSPPFQ LLNFKTWHMC MVSIHKLLVG
     NVEDVNYVST NAHYQAYLRD FTESLNYEKR FWYHLSELGL KKGISAYKHS AAVTYGSAAH
     KQMLANATLV FEEEGRGPYA ELALAKLNDV CLRYWHDGRQ QCEFPSLRGN PCILPRDVSH
     DKHSSGVVHI SSCNCGRTLG RREDPYTLRQ ANYDYYEHMA VMCNLCVKVK RFQFPVFTPS
     ISDYRAAAFE AAFPLLLQAH KNRAEPQVEE DSDQEANAAE EPYSQPATEA EPEPEKEPQA
     SANEWSQPMS ATYGSDLNMS IAGFGVSLKE GGAEAEVEEA EVCDKGSQDN STSSDTSTES
     EIELQPKERS AQKANQILIS TTEYLPGLVH MCSGLELLPL FPSWSLACVG PSSIYSHNTG
     LQEHFQSGFL SGANYLLPWD VQVRLVQPHY KHQQQQLMGK KNQRYRKQGD RLALKIFIGF
     EYECSRGHRF MMRSPERVLR GGADIERDTS TKVINNNMPL YFPCPCRAQN TFLAQLMRIH
     VVTPKAPVNI ILDPKVLVGK YTFTLGCSIL PMLSQSAYWI LRLPYVYQGD NEIIAPPEKI
     EPTNRLAGGC ILAGLFGIAE TESMELKEPR ITSMTFTRLQ SHAYK