ID   SMG8_DROMO              Reviewed;         967 AA.
AC   B4KKN5;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GI17817;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; CH933807; EDW12699.1; -; Genomic_DNA.
DR   RefSeq; XP_002003257.1; XM_002003221.2.
DR   AlphaFoldDB; B4KKN5; -.
DR   STRING; 7230.FBpp0167034; -.
DR   PRIDE; B4KKN5; -.
DR   EnsemblMetazoa; FBtr0168542; FBpp0167034; FBgn0140558.
DR   GeneID; 6577290; -.
DR   KEGG; dmo:Dmoj_GI17817; -.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   InParanoid; B4KKN5; -.
DR   OMA; HCTVKDS; -.
DR   OrthoDB; 645776at2759; -.
DR   PhylomeDB; B4KKN5; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..967
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378175"
FT   REGION          627..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        642..674
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        687..702
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   967 AA;  109269 MW;  D53ECEBC6883DED7 CRC64;
     MSSKSYYTWK YPDIPENVES MLAELNNSLV VVGVIGRSRG PQANKMSAFD MRPNKLHEPA
     DGQILCYYKP GTNTLMLHFE TTYDEAVLSQ QLLSQTSIDF DNFYYRMRSR FVRNMLLALH
     VCHIVVYVDT AEIFDTTLVT ICQLLKYVRE QHVLEFLPQM LHETSVGLML GDRARPCTPR
     MLFLFENYPR DEEKTRDHIS SYEFKTEDQI YHLLRQYNIL TNNVNTSLVA LPNNKQFVFY
     NAHEELHPDQ LSHAIEALNT TMNKPDAKEE DEDLDIISLA PFEGFVKPFG ADYKTRDSKE
     LDYKKNHTAW HFLQRHVQDA LQGYFDEGSF KLLTQTPQYQ LLSARDWHSC MAEIYRLLIQ
     NVHDANYVTD NTNYQAYLRE LNESLNYEKK FWCHLCELGL KKGVSAYRNA APAIYGSATH
     NQLLADATLA FEEEGRGPYV EMALAKLSDV CLKYWHDGRQ QCEQLSLRGH PCTLPKDLAH
     DKHSSGIVHI SSCNCGRTQG RREDPFTLRQ ANYDYYEQLA VMCNLCVKVK KFQFPLFTPS
     ISDYRAAAFE AAFPLLLASK NRLEPAVQGD SDLDAEAADE LYSQPIKAAE PAPQKQLQTL
     GDCCSQPLSA TYGSDLNMSI AGFGDSLNEG EDADADADSP EIRSQICSSG QSSRSRSNSS
     SSDTSSANTE NELVLQLKER SDQKNATEAL SESCPESQSV ASMPELVSTT EYLPGLVHMC
     SACELLPLFP SWSLACVGPS SIYSHNTGLQ EHFQSGFLSG ANFLLPWDVH VRLLQPHHKH
     PPLQQMGKKN QRYRKQGDRL ALKIFVGFEY ECSRGHRFMM CSPDRVLRGG ADIERDTCSK
     LVNNNMPLYF PCPCRGQVSF LAQLMRIHVV TPKAPVNIIV DPKVRVGKYT FTLGCTVLPR
     LSQSAYWILR FPYVYQGDNV LIAPPAKFEP DDPFASGCLL AGMFGIAETD TTDAIQSAGA
     PLNFTRL