ID   SMG8_DROPE              Reviewed;         953 AA.
AC   B4GH42;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GL17013;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; CH479183; EDW35812.1; -; Genomic_DNA.
DR   RefSeq; XP_002017973.1; XM_002017937.1.
DR   AlphaFoldDB; B4GH42; -.
DR   STRING; 7234.FBpp0181120; -.
DR   EnsemblMetazoa; FBtr0182628; FBpp0181120; FBgn0154617.
DR   GeneID; 6592368; -.
DR   KEGG; dpe:6592368; -.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   OMA; HCTVKDS; -.
DR   PhylomeDB; B4GH42; -.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..953
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378176"
FT   REGION          571..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   953 AA;  108351 MW;  71D738ACC60DD1AF CRC64;
     MGLKDYYTWT FPNIPEHVAQ ELDQLGRSLV VVGVIGRSRC VLANKMRAFG MEPPVDHEPT
     DGQLQCYYKP GSSTLLLHFE TTFDDAILGQ QIDETMEQDG APFDFDGFYE RMKCRFVRMM
     LLALHVCHIL VYVETGQTFD LSLVTIFQLM KFAREQHLMQ FLPSLLKETP AGRLLGEKCR
     LCTPRILFLF ENFTHEEGKT RECVSACEFQ TEDSIYELLR HHQIITNSSS SSLLALPNNK
     QFVFYNAHDQ LHADRLLQSI EFLNLDMRKL DVKEEEDDLE VLELAPFDGF VKSFGESFES
     TNYEEQQYKT EHTAWHFLQR HVQDALLGCF DEGSFKQVPQ RGQLQLLNAQ EWHDCIAELH
     KLLVSSAGTQ ESLNEIRNED YQVFLQSFDE SLNYEKKFWA HLCEIGLKMG IEAYKKAAPA
     IYGSSMHQQL LAEATLAFEE EGRGPPAEAS IAKMTATCLR HWQDGRQQCE QLSLRSQPCT
     QPKEMPHDKH NSGVIHVSSC NCGRTQGRRE DPFSLRQANY EFYEHMVKMC NLCVKVKQFK
     FPIFEPTNNE YRAAAFEVAF PLLHAGKNRL AQDAELDPDE EDEELPTGER EEQHITQSNG
     CSQPLSPTFG SDLNMSIAGF GVSLNESEPC FDQSSSSEAE STCSGTSSEE SNNELVLQLK
     EPAKKHEESC DPDSIAPLPS MCLTSTTEYL PGLVHTLSKV GLLPLFPSWS LACVGPSSIY
     SHNTGLQEHF QSGFLSGANF LLPWDVQLRL VHASKHYHNS HQPHMSKKQQ RYRKHGDRMV
     LKIFVGFEYE CSRGHRFMMC RPDRVLRGGA DIERDTCSKM VHTNMPLYYP CPCRSQNNYL
     AQLMRIHVVT PKAPVNIIVD PKVCMGKDKY TFTLGSMVPP RLSQSAYWIL RLPYVYQGDD
     ALIAPPEKLE PDDIMAGGYL LAGMFGIAET DPTLDLNDQG HLDTNELGTF TRI