ID   SMG8_DROPS              Reviewed;         953 AA.
AC   B5E0H4;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GA24994;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM000071; EDY69345.1; -; Genomic_DNA.
DR   RefSeq; XP_002138787.1; XM_002138751.2.
DR   AlphaFoldDB; B5E0H4; -.
DR   SMR; B5E0H4; -.
DR   STRING; 7237.FBpp0278453; -.
DR   EnsemblMetazoa; FBtr0280015; FBpp0278453; FBgn0246377.
DR   GeneID; 6898813; -.
DR   KEGG; dpo:Dpse_GA24994; -.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   InParanoid; B5E0H4; -.
DR   OMA; HCTVKDS; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0246377; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..953
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378177"
FT   REGION          571..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   953 AA;  108360 MW;  B25C7A08804F8729 CRC64;
     MGLKDYYTWK FPNIPEHVAQ ELDQLGRSLV VVGVIGRSRC VLANKMRAFG MEPPVDHEPT
     DGQLQCYYKP GTSTLLLHFE TTFDDAILGQ QIDETMEQDG APFDFDGFYE RMKCRFVRMM
     LLALHVCHIL VYVETGQTFD LSLVTIFQLM KFGREHHLIQ FLPSLLKETP AGRLLGEKCR
     LCTPRILFLF ENFTQEEGKT RECVSACEFQ TEDSIYELLR HHQIITNSSS SSLLALPNNK
     QFVFYNAHDQ LHADRLLQSI EFLNLDMRKV DVKEEDDDLE VLELAPFNGF VKSFGESFEN
     TNYEEQQYKT EHTAWHFLQR HVQDALLGCF DEGSFKQVPQ RGQLQLLNAQ EWHDCIAELH
     KLLVSSAGTQ ESLNEIRNED YQVFLQSFDE SLNYEKKFWA HLCEIGLKMG IEAYKKAAPA
     IYGSSMHQQL LAEATLAFEE EGRGPPAEAS IAKMTATCLR HWQDGRQQCE QLSLRSQPCT
     QPKEMPHDKH NSGVIHVSSC NCGRTQGRRE DPFSLRQANY EFYEHMVKMC NLCVKVKQFK
     FPIFEPTNNE YRAAAFEVAF PLLHAGKNRL AEDAELDPDE EDEELPTGER EEQHITQSNG
     CSQPLSPTFG SDLNMSIAGF GVSLNESEPC FDQSSSSEAE STCSGTSSEE SNTELVLQLK
     EPAKKHEESC DPDSIAPLPS MCLTSTTEYL PGLVHTLSKV GLLPLFPSWS LACVGPSSIY
     SHNTGLQEHF QSGFLSGANF LLPWDVQLRL VHATKHYHNS HQPHMSKKQQ RYRKHGDRMV
     LKIFVGFEYE CSRGHRFMMC RPDRVLRGGA DIERDTCSKM VHTNMPLYYP CPCRSQNNYL
     AQLMRIHVVT PKAPVNIIVD PKVCMGKDKY TFTLGSMVPP RLSQSAYWIL RLPYVYQGDD
     ALIAPPEKLE PDDIMAGGYL LAGMFGIAET DPTLDLNDQG HLDTNELGTF TRI