ID   SMG8_DROSE              Reviewed;         927 AA.
AC   B4HWV2;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GM11479;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; CH480818; EDW52497.1; -; Genomic_DNA.
DR   RefSeq; XP_002036574.1; XM_002036538.1.
DR   AlphaFoldDB; B4HWV2; -.
DR   STRING; 7238.B4HWV2; -.
DR   PRIDE; B4HWV2; -.
DR   EnsemblMetazoa; FBtr0194464; FBpp0192956; FBgn0166422.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   OMA; HCTVKDS; -.
DR   PhylomeDB; B4HWV2; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..927
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378178"
FT   REGION          543..581
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          611..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   927 AA;  105240 MW;  25AB78CAD70D7011 CRC64;
     MLDDYYTWTY PDIPENVAQE LLQLNGSLVV VGVVGRSDCD LANKMLAFGM EPPDDHTPED
     GQIQCYYKPG TFSLLLHFES TYDAEISGQM IDVCIEDVDT PFDIDSFFER IRCRFVRMML
     LALHVCHIVV WAKFAREQHL MQFLPQMLRE TPAARISERT RLCAPRILFL FENFPGDEPK
     TRESVSTCEF QMEDCIYELL RRYNIVTNSS SNSLVALPNN KQFVFFNAHE ELRDDKLLKA
     IDCLNETMYK PDLKEEEEDL EILAMAPFDG FVKPFTMPVY EKEWENLQYQ EDHTVWNFLQ
     RHVHDALVGC FDAGSFKQHA QQGPFQLLNS REWHDCMATM HKLLVENAKD PDHETSNEEY
     KLFLKNFDED LNYEKKFWAH LCELGLKKGI AAYKNAAPAN YGTATHRQLL ADATLAFEEE
     GRGPQAQAAL AKLAAICHKH WEDGRQQCEQ LSLRSHPCTL PKNMPHEKHN SGVIHISTCN
     CGRTQGRRED PFNLRQANYE FYEHIAQMCN LCVKVKQYQF PIFEPSVSDY RAAAFEAAFP
     LLNTGKSGAP QDEDAGEDEA EEEEGQEREL PTKKQLQNTA SNCCSHPLSP TFGSDLNMSI
     AGFGASLKES QARSEQLSNS EQNTTRSGSS SVDTENELVV ELQEPAKKEA REDVGPTDAV
     STSTTEYLPG LVHTVSNFDL LPLFPSWSLA CVGPSSIYSH NTGLQEHFQS GFLSGANFLL
     PWDVQLRLVH ALKQQYQHHH HGKKQQRWKK QGDRLSLKIF VGMEYECSRG HRFMMCAPDR
     VLRGGADIER DTCSKVVHNN MPLYYPCPCR SQKNFLAQLM RIHVVTPKAP VNIIVDPKVC
     VGRYTFTLGS ILPPRLSQSA YWIIRLPYVY QGDDVLIAPP DQLDPDYPLA GGYLLPGMFG
     VVETDPTLDL NEPGMMGASA AGNFTRI