ID   SMG8_DROSI              Reviewed;         944 AA.
AC   B4Q9T2;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GD22229;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; CM000361; EDX04599.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4Q9T2; -.
DR   SMR; B4Q9T2; -.
DR   STRING; 7240.B4Q9T2; -.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   OMA; HCTVKDS; -.
DR   PhylomeDB; B4Q9T2; -.
DR   Proteomes; UP000000304; Chromosome 2l.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..944
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378179"
FT   REGION          560..597
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          628..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   944 AA;  106712 MW;  D57478BE66F3B2FC CRC64;
     MLDDYYTWTY PDIPENVAQE LLQLNGSLVV VGVVGRSDCD LANKMLAFGM EPPDDHTPED
     GQIQCYYKPG TFSLLLHFES TYDAEISGQM IDVCIEDVDT PFDIDSFFER IRCRFVRMML
     LALHVCHIVV YVENGLTFDP TLLTVFQLAK FAREQHLMQF LPQMLRETPA ARISERTRLC
     APRILFLFEN FPGDEPKTRE SVSTCEFQME DCIYELLGRY NIVTNSSSNS LVALPNNKQF
     VFFNAHEELR DDKLLKAIDC LNETMYKPDL KEEEEDLEIL AMAPFDGFVK PFTMPVYEKE
     WENLQYQEDH TVWNFLQRHV QDALVGCFDA GSFKQHAQQG PFQLLNSQEW HDCMATMHKL
     LVENAKDPDH ETSNEEYKLF LKNFDEDLNY EKKFWAHLCE LGLKKGIAAY KNAAPANYGT
     ATHRQLLADA TLAFEEEGRG PQAQAALAKL AAICHNHWED GRQQCELLSL RSHPCTLPKN
     MPHEKHNSGV IHISTCNCGR TQGRREDPFN LRQANYEFYE LIAQMCNLCV KVKQYQFPIF
     EPSVSDYRAA AFEAAFPLLN TGKSGAPQDE DAGEDEAEEE EGQERELPTK KKLQNTASNC
     CSHPLSPTFG SDLNMSIAGF GASLKESQAS SEQLSNSEQN TTSSGTSSAD TENELVVELQ
     EPAKKEARED VGPTDAVSTS TTEYLPGLVH TVSNFGLLPL FPSWSLACVG PSSIYSHNTG
     LQEHFQSGFL SGANFLLPWD VQLRLVHALK QQYQQQHHGK KQQRWKKQGD RLSLKIFVGM
     EYECSRGHRF MMCAPDRVLR GGADIERDTC SKVVHNNMPL YYPCPCRSQR NFLAQLMRIH
     VVTPKAPVNI IVDPKVCVGR YTFTLGSIVP PRLSQSAYWI IRLPYVYQGD DVLIAPPDHL
     DPDYPLAGGY LLPGMFGVVE TDPTLDLNEP GMMGASAAGN FTRI