ID   SMG8_DROVI              Reviewed;         962 AA.
AC   B4LS82;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GJ17645;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
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DR   EMBL; CH940649; EDW64768.1; -; Genomic_DNA.
DR   RefSeq; XP_002052613.1; XM_002052577.2.
DR   AlphaFoldDB; B4LS82; -.
DR   STRING; 7244.FBpp0232062; -.
DR   PRIDE; B4LS82; -.
DR   EnsemblMetazoa; FBtr0233570; FBpp0232062; FBgn0204814.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   InParanoid; B4LS82; -.
DR   OMA; HCTVKDS; -.
DR   OrthoDB; 645776at2759; -.
DR   PhylomeDB; B4LS82; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..962
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378180"
FT   REGION          634..661
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   962 AA;  108301 MW;  4B04C8CA9BCDE700 CRC64;
     MSYKNYYTWK YPDIPEHVAP LLLELQNSLV IVGIIGRSKC AQANKMSAFG MQPDKTHEPA
     DGQILCYYKP GTNMLLLHFE TTHDEAVLGQ QLLKQTSVDF DSFYEQMRSR FLRMLLLALH
     VCHILVYVET AQTFDTTLVT ICQLLKYVRE KHVLDFLPQM LRETAAGSLL SDRARLCTPR
     VLFLFENYPQ DEEKSRERIS AYEFQTEDKI YELLRQYNIV TNNANNSLFA LPNNKQFVFY
     NAHEKLRPDQ LLLAIEALNA TMYKSDSKEE EEDTEILELA PFEGFVKPYG AGYEARESDE
     QLYRKKHTVW HFLQRHVQDA LQGCFDEGSF KQLPQSAQFQ LLGVNDWHIC MDTIHRLLIG
     NIQEVSYVTN NQNYKAYLRD FNESLNYEKK FWGHLCDLGL KKGISAYKSS APAIYGSVTH
     RQLLADAILA FEEEGRGPYA ELALAKLSEI CLRHWHDGRQ QCEQLSLRGN PCTQPKDAPH
     DKHSSGIVHI SSCNCGRTQG RREDPFTLRQ ANYDYYEHMA AMCNLCVKVK KFQLPVFTPS
     ISDYRAAAFE AAFPLLLQAA KNRTEIATGG DSDLEAAGEL YSQPINATEQ APQKPQITLS
     NGCSQPALSA TYGSDLNMSI AGFGASLNEG EEVRSPEISS QIASSGLSSR SNSTSSGTSS
     ANTANELVLQ LKERTDQNAA NAAVSEICPE ALPIVASTEQ VSTTEYLPGL VHMSSGCELL
     PLFPSWSLAC VGPSSIYSHN TGLQEHFQSG FLSGANFLLP WDVHVRLVQP HKHPQQQQQS
     MGKKSQRYRK HGDRLALKIF VGFEYECSRG HRFMMCSPDR VLRGGADIER DTSSKVVNNN
     MPLYFPCPCR AQPTYLAQLM RIHVVTPKAP VNIILDPKMC VGKYTFTLGC PTLPRLSQSA
     YWILRLPYVY QGDNVLITPP ERLEPDDNMA SGCLLAGMFG IAETDTNETN QQAITPLTFT
     RL