ID   SMG8_DROWI              Reviewed;         953 AA.
AC   B4MV81;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GK15451;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH963857; EDW76426.1; -; Genomic_DNA.
DR   RefSeq; XP_002065440.1; XM_002065404.1.
DR   AlphaFoldDB; B4MV81; -.
DR   STRING; 7260.FBpp0244594; -.
DR   EnsemblMetazoa; FBtr0246102; FBpp0244594; FBgn0217456.
DR   GeneID; 6641829; -.
DR   KEGG; dwi:6641829; -.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   InParanoid; B4MV81; -.
DR   OMA; HCTVKDS; -.
DR   OrthoDB; 645776at2759; -.
DR   PhylomeDB; B4MV81; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..953
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378181"
FT   REGION          621..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        626..640
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   953 AA;  108803 MW;  EF1794B2967E4F05 CRC64;
     MIMDYHSWVY PNIPEDANRQ LLKLGDSLVV VGVLGRSRNR HANKMQAFDM KPNSSNYQPI
     EGQILCYFTP GTSTLFLHFE TPWDEVILSK LLLEEKDPEK FDFDQFYETT RNRFIRHMTL
     ALHVCHILVY VETAQIFDMK LVTIFQLLKQ VREQQIMQFA PQLLAELPLV GRGVKCRLCT
     PRILFLFENY PHDEEKTKET ISAYEFQTED SIYQLLRHHN IVTNSSSSSL LALPNNKQFV
     FYNAYEDLHP DRLLQAIDSL NRAIQKTDLK EDEEDLEILE LSPFEGFVKP FGEFPVSRAI
     LLNPKDEEEQ YKKDHTAWHF LQRHVQDALQ NCFDEGSFKQ GSPQGQQFQR LNINDWHKWM
     DNLYKILIAN VANSNYETNN EDYRVYLRNF DQSLNYERKF WLHLCELGLK KGISCYKHSV
     PAFYGQETHD KLLAEAILAF EEEGRGPPSE ATRAKLSAIC LKYWQDGRQQ CEQLSLRRHP
     CTQAKEAPHE KHASGIIHVS SCNCGRTQGR REDPFTLRQA NYEFYEYMAQ ICNLCVKVKQ
     YQFPIFEPSV SDYRAAAFEA AFPLLHGGKP NAEGGEQAAG ACEEDEQLTN GCSQPLSATF
     GSDLNMSIGD FDSLLEGSQV EEPEISYGSA DEDDEESLSN TNESLSENTE NELVLQFKGP
     QKAANNDDEL DETETIVQSS GGYSNSTTEY LPGLVHTFSN PSLLPMFPSW SLACVGPSSI
     YSHNTGLQEH FQSGFLSGAN FLLPWDVHVR LVQAQKNQHH LQQMGKKHLQ RYRKSHLSGG
     DRLTLKIFVG FEYECSRGHR FMMCSPERVL RGGADIERDT SHKVVHQNMP LYYPCPCRSQ
     SNYLAQLMRI HVVTPKAPVN IILDPRVCVG QYTFTLGTVS PPRLSQSAYW MLRLPYVYQG
     DDNLLTPPQK LEADDILSGG YLLAGMFGVA ETEANATSAP TLDTPATANF MRI