ID   SMG8_DROYA              Reviewed;         950 AA.
AC   B4P0U1;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG8 {ECO:0000250|UniProtKB:Q8ND04};
DE   AltName: Full=Protein smg-8 homolog;
GN   ORFNames=GE13372;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       nonC and recruited to stalled ribosomes (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG8 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM000157; EDW87986.1; -; Genomic_DNA.
DR   RefSeq; XP_002088274.1; XM_002088238.2.
DR   AlphaFoldDB; B4P0U1; -.
DR   SMR; B4P0U1; -.
DR   STRING; 7245.FBpp0258382; -.
DR   EnsemblMetazoa; FBtr0259890; FBpp0258382; FBgn0231051.
DR   GeneID; 6527180; -.
DR   KEGG; dya:Dyak_GE13372; -.
DR   eggNOG; KOG3692; Eukaryota.
DR   HOGENOM; CLU_008116_0_0_1; -.
DR   OMA; HCTVKDS; -.
DR   OrthoDB; 645776at2759; -.
DR   PhylomeDB; B4P0U1; -.
DR   Proteomes; UP000002282; Chromosome 2L.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR028802; SMG8.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   PANTHER; PTHR13091; PTHR13091; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay.
FT   CHAIN           1..950
FT                   /note="Nonsense-mediated mRNA decay factor SMG8"
FT                   /id="PRO_0000378182"
FT   REGION          560..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          624..651
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..584
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..607
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   950 AA;  107692 MW;  AD2F3F457E19F360 CRC64;
     MMKDYYTWTY PDIPENVSQE LRQLKSSLVV VGIVGRSKCD QANKMQAFGM EPPIEHKAKE
     GQVQCYYKLG TSSLLLHFET TYDEAILGQM IDVCMEDVET PFDFDSFYER MRCRFVRMML
     LALHACHIVV YVETGQTFDP TLVTVFQLLK FAREQHLMQF LPQMLRETPS ARMSERARLC
     APRILFLFEN FPRDEPKTRE CVSAYEFQTE DCIYELLRHH NIVTNSSSSS LVALPNNKQF
     VFFNAHEQLH EDKLLKAIDC LNQAMYKPDA KEEEEDLEIL ELAPFEGFVK PYNLPVDDKE
     LEKQQYKQDH TVWHFLQRHV QDALLGCFDE GSFKQHSQQG QFQLLNIHEW HNYMATLHKL
     LVENAKDPNQ ETSNEDYKLF LKSFDESLNY EKKFWAHLCE LGLKKGIAAY KNAAPANYGN
     STHRQLLADA TVAFEEEGRG PQAKAALAKM AAICQKHWQD GRQQCEQLSL RSHPCTLPKN
     LPHEKHNSGV IHISSCNCGR TQGRREDPFN LRQANYEFYE HIAQMCNLCV KVKQYQLPIF
     EPSVSDYRAA AFEAAFPLLH TGKSGAPQDE DGEEDAEDEE GQEQQQPAEE QRQNTASNGC
     SQPLSPTFGS DLNMSIAGFG ASLNESQASS EQLSNSEQNS TSSGTSSADT ENELVVELQE
     LHAKKEARDD AGPADAFSTS TTEYLPGLVH TVSNFGLLPL FPSWSLACVG PSSIYSHNTG
     LQEHFQSGFL SGANFLLPWD VQLRLVHAPK QQHHTHHQQQ HLGKKQQRWK KQGDRLSLKI
     FVGMEYECSR GHRFMMCAPD RVLRGGADIE RETCSKVVHN NMPLYYPCPC RSQTSYLAQL
     MRIHVVTPKA PVNIIVDPKV CVGKGKYTFT LGSIVPPRLS QSAYWIIRLP YVYQGDDVLI
     APPEKLEPDD PLAGGYLLPG MFGVAETDPT LDLNEPGRMG ASAAGNFTRI