ID   SMG9_BOVIN              Reviewed;         520 AA.
AC   Q2YDD2;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG9 {ECO:0000250|UniProtKB:Q9H0W8};
GN   Name=SMG9 {ECO:0000250|UniProtKB:Q9H0W8};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Is recruited by release factors to stalled
CC       ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase
CC       complex) and, in the SMG1C complex, is required for the efficient
CC       association between SMG1 and SMG8 (By similarity). Plays a role in
CC       brain, heart, and eye development. {ECO:0000250|UniProtKB:Q9DB90,
CC       ECO:0000250|UniProtKB:Q9H0W8}.
CC   -!- SUBUNIT: Self-associates to form homodimers and forms heterodimers with
CC       SMG8; these assembly forms may represent SMG1C intermediate forms (By
CC       similarity). Component of the SMG1C complex composed of SMG1, SMG8 and
CC       SMG9. Self-associates to form homodimers and forms heterodimers with
CC       SMG8; these assembly forms may represent SMG1C intermediate forms (By
CC       similarity). Interacts with DHX34; the interaction is RNA-independent
CC       (By similarity). {ECO:0000250|UniProtKB:Q9H0W8}.
CC   -!- PTM: Phosphorylated by SMG1. {ECO:0000250|UniProtKB:Q9H0W8}.
CC   -!- SIMILARITY: Belongs to the SMG9 family. {ECO:0000305}.
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DR   EMBL; BC110277; AAI10278.1; -; mRNA.
DR   RefSeq; NP_001040024.1; NM_001046559.1.
DR   AlphaFoldDB; Q2YDD2; -.
DR   SMR; Q2YDD2; -.
DR   STRING; 9913.ENSBTAP00000015684; -.
DR   PaxDb; Q2YDD2; -.
DR   GeneID; 615492; -.
DR   KEGG; bta:615492; -.
DR   CTD; 56006; -.
DR   eggNOG; KOG4181; Eukaryota.
DR   InParanoid; Q2YDD2; -.
DR   OrthoDB; 1436399at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:0001654; P:eye development; ISS:UniProtKB.
DR   GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   InterPro; IPR039177; SMG9.
DR   PANTHER; PTHR14270; PTHR14270; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nonsense-mediated mRNA decay; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0W8"
FT   CHAIN           2..520
FT                   /note="Nonsense-mediated mRNA decay factor SMG9"
FT                   /id="PRO_0000289162"
FT   REGION          1..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..56
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..96
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0W8"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0W8"
FT   MOD_RES         4
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0W8"
FT   MOD_RES         7
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0W8"
FT   MOD_RES         32
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0W8"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0W8"
FT   MOD_RES         451
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H0W8"
SQ   SEQUENCE   520 AA;  57638 MW;  97F5B8FC9805ACDA CRC64;
     MSESGHSQPG LYGIERRRRW KEPGPGGPQN LSGPGGRERD YIAPWERERR DGSEETSTAV
     MQKTPIILSK PPAERSKQPP PPAAPAAPPA PAPLEKPIVL MKPREEGKGP AATTSTSTPE
     GTAPPPPAAP VPPKGEKEGQ RPTQPVYQIQ NRGMGTAAPA AMDPVVGQAK LLPPERMKHS
     IKLVDDQMNW CDSAIEYLLD QTDVLVVGVL GLQGTGKSMV MSLLSANTPE EDQRAYVFRA
     QSAEMKERGG NQTSGIDFFI TQERIVFLDT QPILSPSILD HLINNDRKLP PEYNLPHTYV
     EMQSLQIAAF LFTVCHVVIV VQDWFTDLSL YRFLQTAEMV KPSTPSPSHE SSSSSGSEEG
     AEYYPHLVFL QNKARREDFC PRKLRQMHLM IDQLMAHSHL RYKGTLSMLQ CNVFPGLPPD
     FLDSEVNLFL MPFMDSETES ETPPRAGPGS SPLFSLLPGY RGHPSFQSLV SKLRSQVMSM
     ARPQLSHTIL TEKNWFHYAA RIWDGVKKSS ALAEYSRLLA