ID   SMG9_CAEBR              Reviewed;         382 AA.
AC   A8WX27;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG9 {ECO:0000250|UniProtKB:Q9H0W8};
DE   AltName: Full=Suppressor with morphogenetic effect on genitalia protein 9 {ECO:0000312|WormBase:CBG04259};
GN   Name=smg-9; ORFNames=CBG04259;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Probable component of kinase complex containing
CC       smg-1 and recruited to stalled ribosomes (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG9 family. {ECO:0000305}.
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DR   EMBL; HE600920; CAP25003.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WX27; -.
DR   SMR; A8WX27; -.
DR   STRING; 6238.CBG04259; -.
DR   EnsemblMetazoa; CBG04259.1; CBG04259.1; WBGene00026972.
DR   WormBase; CBG04259; CBP34379; WBGene00026972; Cbr-smg-9.
DR   eggNOG; KOG4181; Eukaryota.
DR   HOGENOM; CLU_698769_0_0_1; -.
DR   InParanoid; A8WX27; -.
DR   OMA; SFSIMEG; -.
DR   OrthoDB; 1436399at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039177; SMG9.
DR   PANTHER; PTHR14270; PTHR14270; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..382
FT                   /note="Nonsense-mediated mRNA decay factor SMG9"
FT                   /id="PRO_0000378185"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   382 AA;  43672 MW;  AAE2C321286D002F CRC64;
     MKKVEILKTP VIQQRPVAPS RTSSPPVTAP RIAIKPRPPP ASGNSGIPEN NGPISPPDSS
     VSKSSGMKES VRFLNDIGEI TDSISDLLTN SPNFNVISAI GPQGAGKSTI LSMLAGNNSR
     QMYREYVFRP VSREANEQSR HQTTQIDIYV TNHQIFLDCQ PMHSFSIMEG LPKLRGGRLD
     EATAMSDTLR LTAFLLFISH TVLVISETHF DKTIIDTIRT SEQIRPWLHQ FRPKLSIERM
     TNLVFIKTKA SSIDTAPSVI RERAQLLRLA FRDSKWLKIS KEPFKCLLVL EEIRVKREHL
     YEGEDEIDET MLNEFDEHIA QLRVMLQRNR DDFTVETAAM DEKKWLEMCQ EVIRDKTFHR
     ILKEFHRSDR DRSSIYAENG DR