SMG9_CAEEL
ID SMG9_CAEEL Reviewed; 385 AA.
AC Q9XWJ1;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Nonsense-mediated mRNA decay factor SMG9 {ECO:0000250|UniProtKB:Q9H0W8};
DE AltName: Full=Suppressor with morphogenetic effect on genitalia protein 9 {ECO:0000312|WormBase:Y54E2A.2};
GN Name=smg-9; ORFNames=Y54E2A.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19417104; DOI=10.1101/gad.1767209;
RA Yamashita A., Izumi N., Kashima I., Ohnishi T., Saari B., Katsuhata Y.,
RA Muramatsu R., Morita T., Iwamatsu A., Hachiya T., Kurata R., Hirano H.,
RA Anderson P., Ohno S.;
RT "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate
RT remodeling of the mRNA surveillance complex during nonsense-mediated mRNA
RT decay.";
RL Genes Dev. 23:1091-1105(2009).
CC -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC premature stop codons. Probable component of kinase complex containing
CC smg-1 and recruited to stalled ribosomes.
CC {ECO:0000269|PubMed:19417104}.
CC -!- DISRUPTION PHENOTYPE: Defects in nonsense-mediated decay (NMD).
CC {ECO:0000269|PubMed:19417104}.
CC -!- SIMILARITY: Belongs to the SMG9 family. {ECO:0000305}.
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DR EMBL; AL032646; CAA21676.1; -; Genomic_DNA.
DR PIR; T27143; T27143.
DR RefSeq; NP_497058.1; NM_064657.1.
DR PDB; 5NKK; X-ray; 2.64 A; B/D/F=59-375.
DR PDB; 5NKM; X-ray; 2.49 A; B=59-375, D/F=59-363.
DR PDBsum; 5NKK; -.
DR PDBsum; 5NKM; -.
DR AlphaFoldDB; Q9XWJ1; -.
DR SMR; Q9XWJ1; -.
DR BioGRID; 40413; 1.
DR STRING; 6239.Y54E2A.2; -.
DR EPD; Q9XWJ1; -.
DR PaxDb; Q9XWJ1; -.
DR PeptideAtlas; Q9XWJ1; -.
DR EnsemblMetazoa; Y54E2A.2.1; Y54E2A.2.1; WBGene00013188.
DR EnsemblMetazoa; Y54E2A.2.2; Y54E2A.2.2; WBGene00013188.
DR EnsemblMetazoa; Y54E2A.2.3; Y54E2A.2.3; WBGene00013188.
DR EnsemblMetazoa; Y54E2A.2.4; Y54E2A.2.4; WBGene00013188.
DR GeneID; 175132; -.
DR KEGG; cel:CELE_Y54E2A.2; -.
DR UCSC; Y54E2A.2; c. elegans.
DR CTD; 175132; -.
DR WormBase; Y54E2A.2; CE20301; WBGene00013188; smg-9.
DR eggNOG; KOG4181; Eukaryota.
DR GeneTree; ENSGT00390000003568; -.
DR HOGENOM; CLU_698769_0_0_1; -.
DR InParanoid; Q9XWJ1; -.
DR OMA; SFSIMEG; -.
DR OrthoDB; 1436399at2759; -.
DR PhylomeDB; Q9XWJ1; -.
DR Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:Q9XWJ1; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00013188; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IMP:UniProtKB.
DR DisProt; DP03048; -.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039177; SMG9.
DR PANTHER; PTHR14270; PTHR14270; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nonsense-mediated mRNA decay; Reference proteome.
FT CHAIN 1..385
FT /note="Nonsense-mediated mRNA decay factor SMG9"
FT /id="PRO_0000378186"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 63..66
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 68..70
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 77..79
FT /evidence="ECO:0007829|PDB:5NKM"
FT STRAND 87..92
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 95..97
FT /evidence="ECO:0007829|PDB:5NKK"
FT HELIX 99..107
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 115..117
FT /evidence="ECO:0007829|PDB:5NKM"
FT STRAND 138..143
FT /evidence="ECO:0007829|PDB:5NKM"
FT STRAND 146..151
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 173..190
FT /evidence="ECO:0007829|PDB:5NKM"
FT STRAND 192..202
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 204..213
FT /evidence="ECO:0007829|PDB:5NKM"
FT STRAND 233..239
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 245..247
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 249..262
FT /evidence="ECO:0007829|PDB:5NKM"
FT TURN 263..265
FT /evidence="ECO:0007829|PDB:5NKM"
FT STRAND 267..271
FT /evidence="ECO:0007829|PDB:5NKM"
FT STRAND 277..281
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 306..318
FT /evidence="ECO:0007829|PDB:5NKM"
FT TURN 319..321
FT /evidence="ECO:0007829|PDB:5NKM"
FT STRAND 326..329
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 335..347
FT /evidence="ECO:0007829|PDB:5NKM"
FT HELIX 349..363
FT /evidence="ECO:0007829|PDB:5NKM"
SQ SEQUENCE 385 AA; 43773 MW; C9A1F1F041ACCF5B CRC64;
MKKVEILKTS RPSSAGGAAR PSTASPTHGA PKIAIKTRPV ADDVAPTAAT VIEPSQKAMK
ESVRFLTDFG EISDAISDLL TSSPNFNVIS AIGPQGAGKS TLLSMLAGNN SRQMYREYVF
RPVSREANEQ SRHQTIQIDI YIVNHQIFLD CQPMYSFSIM EGLPKVRGGR FDDSTAMSDT
LRLTAFLLYV SHTVLVVSET HYDKVIIDTL RVAEQIRPYL AIFRPKLAID RKTNLVFIKT
KASSIDLAPT VIREREELLR LSFQDSRWLK VSQEPFKTLI VLEEIRVRRE HLFEEGDEPD
EAASLNEFDE QIAELREELQ KNREDFTVET AAMDEKKWLD MCREVIRDKT LHKTLKEYQR
AMTDGVRTHF DNGFHAERDA NKFFS
