ID   SMG9_SALSA              Reviewed;         505 AA.
AC   B5X165;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG9 {ECO:0000250|UniProtKB:Q9H0W8};
DE   AltName: Full=Protein smg-9 homolog;
GN   Name=smg9;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Is recruited by release factors to stalled
CC       ribosomes together with smg1 and smg8 (forming the SMG1C protein kinase
CC       complex) and, in the SMG1C complex, is required for the efficient
CC       association between smg1 and smg8 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SMG1C complex composed of smg1, smg8 and
CC       smg9. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG9 family. {ECO:0000305}.
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DR   EMBL; BT044784; ACI33046.1; -; mRNA.
DR   RefSeq; NP_001133333.1; NM_001139861.1.
DR   RefSeq; XP_014056854.1; XM_014201379.1.
DR   AlphaFoldDB; B5X165; -.
DR   SMR; B5X165; -.
DR   STRING; 8030.ENSSSAP00000004709; -.
DR   GeneID; 100194832; -.
DR   KEGG; sasa:100194832; -.
DR   CTD; 56006; -.
DR   Proteomes; UP000087266; Chromosome ssa05.
DR   Bgee; ENSSSAG00000002370; Expressed in head kidney and 16 other tissues.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR019354; SMG8/SMG9.
DR   InterPro; IPR039177; SMG9.
DR   PANTHER; PTHR14270; PTHR14270; 1.
DR   Pfam; PF10220; Smg8_Smg9; 1.
PE   2: Evidence at transcript level;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..505
FT                   /note="Nonsense-mediated mRNA decay factor SMG9"
FT                   /id="PRO_0000378183"
FT   REGION          1..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  56289 MW;  1AF5B8FD9E8AFCA2 CRC64;
     MSESGHSQPG MYGQGRRRRR RRDRDVGPPG QNLSGPSRDR EYVPRERRDG SEEPPGPLLQ
     KTPIILAKPP GERSKPSQSV PIGGGQALEK PIMLIKSRED GGKPGTPPEV ASPCSGASKL
     EREGQRPTQP VYQIQNRGMG AAASSGAVDP VIGQTKLVPP EKMKHSIKLV DDQMNWCDSA
     MEYLRDQTDM LVVGVIGLQG TGKSTIMSLL SANAPEEDQR GYVFRAQTQE IKERGGNQST
     GIDFYITQER VIFLDTQPIL SPSILDHLIN NDRKLPPEYN LPHTYVEMQS LQITAFLFTV
     CHVVIVIQDW FTDINLYRFL QTAEMLKPST PSASHDSTGS SGNEEGSEYY PHIVFLQNKS
     SRDEFCPRNL KKMHMAVDKL MAHSHLKYKG TLSMLDCNIF PGLDRDYLET EVNMFLLPLM
     ENEGEDALTK AGSGSAPLFS LLPGYRGHPT FSSQVSKLRS QILAMSRCQL SHTILTEKNW
     FHYAARIWDG VKKSSALSEY SRLQA