ID   SMG9_XENLA              Reviewed;         508 AA.
AC   Q05AW9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG9 {ECO:0000250|UniProtKB:Q9H0W8};
DE   AltName: Full=Protein smg-9 homolog;
GN   Name=smg9;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Is recruited by release factors to stalled
CC       ribosomes together with smg1 and smg8 (forming the SMG1C protein kinase
CC       complex) and, in the SMG1C complex, is required for the efficient
CC       association between smg1 and smg8 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SMG1C complex composed of smg1, smg8 and
CC       smg9. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG9 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC123225; AAI23226.1; -; mRNA.
DR   RefSeq; NP_001090489.1; NM_001097020.1.
DR   AlphaFoldDB; Q05AW9; -.
DR   SMR; Q05AW9; -.
DR   BioGRID; 608109; 1.
DR   IntAct; Q05AW9; 1.
DR   MaxQB; Q05AW9; -.
DR   DNASU; 779402; -.
DR   GeneID; 779402; -.
DR   KEGG; xla:779402; -.
DR   CTD; 779402; -.
DR   Xenbase; XB-GENE-990840; smg9.S.
DR   OrthoDB; 1436399at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 779402; Expressed in ovary and 19 other tissues.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039177; SMG9.
DR   PANTHER; PTHR14270; PTHR14270; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..508
FT                   /note="Nonsense-mediated mRNA decay factor SMG9"
FT                   /id="PRO_0000289166"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   508 AA;  56599 MW;  4957516579A0E90C CRC64;
     MSDSGHSQPN VFIPGRNRRR RWMDQGPAGN LNLSEPGREK DSVLRDRDQE RWEGNDEGCG
     YTIQKTPIIL AKPASDRAKA ATPAAPAPIE KPIVLMKARE EGKPTAPAEG AAVPPAAAVA
     KVEKEGQRPT QPVYQIQNRG MGAAASAGGS VDPVVGQAKL LPPQKMKHSI KLVDEYMNWC
     DSAIEFLLDQ TDVLVVGVLG LQGTGKSTLM SLLSANSPDD DQRSYVFRMQ SQEVRERAGN
     QTSGIDFFIS QERIIFLDTQ PILSPAILDH LINNDRKLPP EYNLPHTYVE MQSLQIAAFL
     FTVCHVVIVV QDWFTDFNLY RFLQTAEMLK PSTPSPSHES SGSSGSDEGI EYYPHIVFVQ
     NKSKREDFCP RTLKQMHTVM DKLMLHSHLR YKGTLSMLDC NIFPGLPYDF VESEVNLFLI
     PTMESDADET ISRAGTSGIP LFSLLPAYKG HPSFHSLVSR LRSQIMSMSR PQLSHTILTE
     KNWFHYAARI WDGVKKSSAL SEYSRLLG