ID   SMG9_XENTR              Reviewed;         508 AA.
AC   B5DDX6;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Nonsense-mediated mRNA decay factor SMG9 {ECO:0000250|UniProtKB:Q9H0W8};
DE   AltName: Full=Protein smg-9 homolog;
GN   Name=smg9;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Heart;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in nonsense-mediated decay (NMD) of mRNAs containing
CC       premature stop codons. Is recruited by release factors to stalled
CC       ribosomes together with smg1 and smg8 (forming the SMG1C protein kinase
CC       complex) and, in the SMG1C complex, is required for the efficient
CC       association between smg1 and smg8 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SMG1C complex composed of smg1, smg8 and
CC       smg9. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMG9 family. {ECO:0000305}.
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DR   EMBL; BC168445; AAI68445.1; -; mRNA.
DR   RefSeq; NP_001135618.1; NM_001142146.1.
DR   RefSeq; XP_012821683.1; XM_012966229.2.
DR   RefSeq; XP_012821684.1; XM_012966230.2.
DR   AlphaFoldDB; B5DDX6; -.
DR   SMR; B5DDX6; -.
DR   PaxDb; B5DDX6; -.
DR   Ensembl; ENSXETT00000008862; ENSXETP00000008862; ENSXETG00000004098.
DR   GeneID; 100216177; -.
DR   KEGG; xtr:100216177; -.
DR   CTD; 56006; -.
DR   Xenbase; XB-GENE-990837; smg9.
DR   eggNOG; KOG4181; Eukaryota.
DR   HOGENOM; CLU_037795_0_0_1; -.
DR   InParanoid; B5DDX6; -.
DR   OMA; TEPILSW; -.
DR   OrthoDB; 1436399at2759; -.
DR   PhylomeDB; B5DDX6; -.
DR   TreeFam; TF319763; -.
DR   Reactome; R-XTR-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004098; Expressed in ovary and 13 other tissues.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039177; SMG9.
DR   PANTHER; PTHR14270; PTHR14270; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Nonsense-mediated mRNA decay; Reference proteome.
FT   CHAIN           1..508
FT                   /note="Nonsense-mediated mRNA decay factor SMG9"
FT                   /id="PRO_0000378184"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   508 AA;  56964 MW;  AA89F4098396FEF4 CRC64;
     MSDSGHSQPN VFIPGRNRRR RWMDQGPPGH LNLSEPGREK DPMLRDRDQD RWEGNEEGYG
     YTIQKTPIIL AKPTSDRTKA ATPAAPPPME KPIVLMKARE DGKPAAPAEG ATAPPPTAVA
     KVEKEGQRPT QPVYQIQNRG MGAAASASGN VDPVVGQAKL LPPQKMKHSI KLVDEYMNWC
     DSAIEFLLDQ TDVLVVGILG LQGTGKSTLM SLLSANSPDD DQRSYVFRMQ SQEVRERAGN
     QTSGIDFFIS QERIIFLDTQ PILSPAILDH LINNDRKLPP EYNLPHTYVE MQSLQIAAFL
     FTVCHVVIVV QDWFTDFNLY RFLQTAEMLK PSTPSPSHES SGSSGSDEGI EYYPHVVFVQ
     NKAKREDYCP RTLKQMHTVI DKLMLHSHLR YKGTLSMLDC NIFPGLPYDF IESEVNLFLI
     PTMESDVDET ISRAGTSGIP LFSLLPAYKG HPSFHSLISR LRSQIMSMSR PQLSHTILTE
     KNWFHYAARI WDGVKKSSAL SEYSRLLG