ID   BIMM_BPT4               Reviewed;          83 AA.
AC   P08986;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   02-DEC-2020, entry version 70.
DE   RecName: Full=Immunity protein;
GN   Name=imm;
OS   Enterobacteria phage T4 (Bacteriophage T4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
OX   NCBI_TaxID=10665;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=2746737; DOI=10.1128/jvi.63.8.3472-3478.1989;
RA   Lu M.J., Henning U.;
RT   "The immunity (imm) gene of Escherichia coli bacteriophage T4.";
RL   J. Virol. 63:3472-3478(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3350013; DOI=10.1111/j.1432-1033.1988.tb13925.x;
RA   Lamm N., Wang Y., Mathews C.K., Rueger W.;
RT   "Deoxycytidylate hydroxymethylase gene of bacteriophage T4. Nucleotide
RT   sequence determination and over-expression of the gene.";
RL   Eur. J. Biochem. 172:553-563(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12626685; DOI=10.1128/mmbr.67.1.86-156.2003;
RA   Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.;
RT   "Bacteriophage T4 genome.";
RL   Microbiol. Mol. Biol. Rev. 67:86-156(2003).
RN   [4]
RP   SUBCELLULAR LOCATION, AND TOPOLOGY.
RX   PubMed=8331731; DOI=10.1128/jvi.67.8.4905-4913.1993;
RA   Lu M.J., Stierhof Y.D., Henning U.;
RT   "Location and unusual membrane topology of the immunity protein of the
RT   Escherichia coli phage T4.";
RL   J. Virol. 67:4905-4913(1993).
CC   -!- FUNCTION: Inhibits of the DNA ejection of T4 into the host cytoplasm.
CC       By this means, T4 excludes superinfection by the phages of the same
CC       family. {ECO:0000269|PubMed:2746737}.
CC   -!- SUBCELLULAR LOCATION: Host cell inner membrane
CC       {ECO:0000269|PubMed:8331731}; Multi-pass membrane protein
CC       {ECO:0000255}.
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DR   EMBL; X07916; CAA30750.1; -; Genomic_DNA.
DR   EMBL; M37159; AAA21708.1; -; Genomic_DNA.
DR   EMBL; AF158101; AAD42582.1; -; Genomic_DNA.
DR   PIR; JF0072; IMBPT4.
DR   RefSeq; NP_049660.1; NC_000866.4.
DR   TCDB; 1.E.9.1.1; the t4 immunity (t4 imm) family.
DR   GeneID; 1258553; -.
DR   KEGG; vg:1258553; -.
DR   Proteomes; UP000009087; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098669; P:superinfection exclusion; IEA:UniProtKB-KW.
DR   InterPro; IPR016410; Phage_imm.
DR   Pfam; PF14373; Imm_superinfect; 1.
DR   PIRSF; PIRSF004305; Phage-assoc_immunity; 1.
PE   1: Evidence at protein level;
KW   Host cell inner membrane; Host cell membrane; Host membrane;
KW   Host-virus interaction; Membrane; Reference proteome;
KW   Superinfection exclusion; Transmembrane; Transmembrane helix.
FT   CHAIN           1..83
FT                   /note="Immunity protein"
FT                   /id="PRO_0000164946"
FT   TRANSMEM        3..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000305|PubMed:8331731"
FT   TRANSMEM        37..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000305|PubMed:8331731"
FT   TOPO_DOM        66..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:8331731"
SQ   SEQUENCE   83 AA;  9342 MW;  17B4010D27994822 CRC64;
     METLVAGSIF MVLVSGVLAI IIYMLPWFIA LMRGSKSTVG IFFASLLFNW SIIGWFITFI
     WSIAGETKKS AQPNQVIIIR EKE