ID   BIN2_CHICK              Reviewed;         476 AA.
AC   Q5ZKL7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Bridging integrator 2;
GN   Name=BIN2; ORFNames=RCJMB04_10b19;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AJ720067; CAG31726.1; -; mRNA.
DR   RefSeq; NP_001074365.1; NM_001080896.2.
DR   AlphaFoldDB; Q5ZKL7; -.
DR   SMR; Q5ZKL7; -.
DR   STRING; 9031.ENSGALP00000042254; -.
DR   PRIDE; Q5ZKL7; -.
DR   GeneID; 777552; -.
DR   KEGG; gga:777552; -.
DR   CTD; 51411; -.
DR   VEuPathDB; HostDB:geneid_777552; -.
DR   eggNOG; KOG3771; Eukaryota.
DR   InParanoid; Q5ZKL7; -.
DR   OrthoDB; 1366218at2759; -.
DR   PhylomeDB; Q5ZKL7; -.
DR   PRO; PR:Q5ZKL7; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0002102; C:podosome; IBA:GO_Central.
DR   GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0097320; P:plasma membrane tubulation; IBA:GO_Central.
DR   GO; GO:0071800; P:podosome assembly; IBA:GO_Central.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR003005; Amphiphysin.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR028827; BIN2.
DR   PANTHER; PTHR46514:SF1; PTHR46514:SF1; 1.
DR   Pfam; PF03114; BAR; 1.
DR   PRINTS; PR01251; AMPHIPHYSIN.
DR   SMART; SM00721; BAR; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   PROSITE; PS51021; BAR; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..476
FT                   /note="Bridging integrator 2"
FT                   /id="PRO_0000256142"
FT   DOMAIN          26..242
FT                   /note="BAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT   REGION          269..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          395..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..325
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..350
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   476 AA;  51180 MW;  F4ADBB9A7ED4256C CRC64;
     MAEGKSGAGL FAKQVQKHFS RAQEKVLQKL GKTVETKDEQ FEQSAYNFQL QQNEGNKLYK
     DLKAFVGAVK VMHESSRKVA ETLQEIYSTE WDGHVELKAI ADSNDLLWDD YEAKLGDQAL
     RLMENYLAQF GDIKERIAKR GRKLVDYDSA RHHLEALQNA KKKDEAKIAK AEEEFNRAQV
     VFEELNRELR EELPVLYGSR IACYVTIFQN ISNLRDIFYK EMSKLNRDLY EVMGKLDKQH
     SSKVFIIKGV PSKRRSLLIS APVSPPAAYP CPGKAPNWEP SSGAEQTPTS PRVGSDATED
     VPNGLAAPGP AEPGAPMPGP PPASPTSVRS ASESESECSG ESREIDLSPK EMEVSAGSGC
     PEYPKTEGAA KGEVEGIAAS MASMIVSEAI AAATGAAPGD SDGVGGGDST DSEISPAEGA
     WGGPSPGGSE ERVEGTDVSP EVGSDAGPCE HGTPEPPEQD VSCNPPQDPS ESLTPL