ID   BIN3D_CAEEL             Reviewed;         378 AA.
AC   Q9U2R0; Q9XXH6;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Probable RNA methyltransferase Y17G7B.18;
DE            EC=2.1.1.-;
GN   ORFNames=Y17G7B.18;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probable RNA methyltransferase. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q9U2R0-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q9U2R0-2; Sequence=VSP_025998;
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL023828; CAA19465.1; -; Genomic_DNA.
DR   EMBL; AL023828; CAA19466.1; -; Genomic_DNA.
DR   PIR; T26511; T26511.
DR   PIR; T26512; T26512.
DR   RefSeq; NP_496572.1; NM_064171.5.
DR   RefSeq; NP_496573.1; NM_064172.3. [Q9U2R0-1]
DR   AlphaFoldDB; Q9U2R0; -.
DR   SMR; Q9U2R0; -.
DR   STRING; 6239.Y17G7B.18b; -.
DR   EPD; Q9U2R0; -.
DR   PaxDb; Q9U2R0; -.
DR   PeptideAtlas; Q9U2R0; -.
DR   EnsemblMetazoa; Y17G7B.18a.1; Y17G7B.18a.1; WBGene00012469. [Q9U2R0-1]
DR   EnsemblMetazoa; Y17G7B.18b.1; Y17G7B.18b.1; WBGene00012469. [Q9U2R0-2]
DR   GeneID; 174850; -.
DR   KEGG; cel:CELE_Y17G7B.18; -.
DR   UCSC; Y17G7B.18a; c. elegans. [Q9U2R0-1]
DR   CTD; 174850; -.
DR   WormBase; Y17G7B.18a; CE19052; WBGene00012469; -. [Q9U2R0-1]
DR   WormBase; Y17G7B.18b; CE19053; WBGene00012469; -. [Q9U2R0-2]
DR   eggNOG; KOG2899; Eukaryota.
DR   GeneTree; ENSGT00940000153993; -.
DR   InParanoid; Q9U2R0; -.
DR   OMA; YCDHETE; -.
DR   OrthoDB; 1185441at2759; -.
DR   PhylomeDB; Q9U2R0; -.
DR   PRO; PR:Q9U2R0; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00012469; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0008171; F:O-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0017069; F:snRNA binding; IBA:GO_Central.
DR   GO; GO:0040031; P:snRNA modification; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR039772; Bin3-like.
DR   InterPro; IPR010675; Bin3_C.
DR   InterPro; IPR024160; BIN3_SAM-bd_dom.
DR   InterPro; IPR025714; Methyltranfer_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR12315; PTHR12315; 1.
DR   Pfam; PF06859; Bin3; 1.
DR   Pfam; PF13847; Methyltransf_31; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51515; BIN3_SAM; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..378
FT                   /note="Probable RNA methyltransferase Y17G7B.18"
FT                   /id="PRO_0000289268"
FT   DOMAIN          136..367
FT                   /note="Bin3-type SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00848"
FT   REGION          1..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         78
FT                   /note="K -> KKLQ (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_025998"
SQ   SEQUENCE   378 AA;  44113 MW;  7F9FB4278BEA02DE CRC64;
     MSSHRRGSFR GRKRFYRDTF APGGSKTDPL NIEIELTENP EEEKKRLGLL DPTTERSKKR
     KVEKDEKSEK PAENSPFKKN QYNSPRKDSR RPPQLSKEEK SAAENRKQKT EYFNKKYRYG
     NFDRYYGIRL NPGESDKRLS VFQKDWFEHK QALDIGCNAG FLTLSIAKDF SPRRIIGIDI
     DEHLIGVARK NIRHYCDHET EVSGKFPASF GVQFGTVSQR NEAPRSFSTK FPDNIWFKKE
     NYVLESDEML DMIQPEFDVI LALSITKWIH LNWGDDGMRR FFRRAYAQLH PGGRLIIEPQ
     AFDSYKKRAK MSEELKANYS KIEFKPEDFE MWLIETVGFE SVEKLGVVGA KSKGFERPID
     VYLKPLHPKT DAIPLGYI