SMH4_MAIZE
ID SMH4_MAIZE Reviewed; 288 AA.
AC Q8W119; Q6WLH2;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Single myb histone 4;
DE AltName: Full=Protein SINGLE MYB HISTONE4;
GN Name=SMH4; Synonyms=HON108;
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. W23;
RX PubMed=14576282; DOI=10.1104/pp.103.026856;
RA Marian C.O., Bordoli S.J., Goltz M., Santarella R.A., Jackson L.P.,
RA Danilevskaya O., Beckstette M., Meeley R., Bass H.W.;
RT "The maize Single myb histone 1 gene, Smh1, belongs to a novel gene family
RT and encodes a protein that binds telomere DNA repeats in vitro.";
RL Plant Physiol. 133:1336-1350(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. B73;
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. B73;
RA Springer N.M., Schmitt L.T., Guthrie E., Sidorenko L., Selinger D.,
RA Kaeppler H.F., Kaeppler S.M.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds preferentially double-stranded telomeric repeats, but
CC may also bind to the single telomeric strand. {ECO:0000250}.
CC -!- SUBUNIT: Forms a homodimer and heterodimers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000255|PROSITE-ProRule:PRU00837}. Chromosome {ECO:0000255|PROSITE-
CC ProRule:PRU00837}. Nucleus, nucleolus {ECO:0000250}. Chromosome,
CC telomere {ECO:0000305}. Note=Localized to the nucleolus during
CC interphase. {ECO:0000250}.
CC -!- DOMAIN: HTH myb-type domain confers double-stranded telomeric DNA-
CC binding while the H15 domain is involved in non-specific DNA-protein
CC interaction and multimerization. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H1/H5 family. SMH subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00837}.
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DR EMBL; AY280631; AAQ62068.1; -; mRNA.
DR EMBL; BT062712; ACN27409.1; -; mRNA.
DR EMBL; AF461815; AAL73044.1; -; mRNA.
DR RefSeq; NP_001105227.2; NM_001111757.2.
DR AlphaFoldDB; Q8W119; -.
DR SMR; Q8W119; -.
DR STRING; 4577.GRMZM2G108424_P02; -.
DR PaxDb; Q8W119; -.
DR EnsemblPlants; Zm00001eb155280_T001; Zm00001eb155280_P001; Zm00001eb155280.
DR GeneID; 542125; -.
DR Gramene; Zm00001eb155280_T001; Zm00001eb155280_P001; Zm00001eb155280.
DR KEGG; zma:542125; -.
DR eggNOG; ENOG502QTN3; Eukaryota.
DR HOGENOM; CLU_047477_1_0_1; -.
DR OMA; CCRDEVV; -.
DR OrthoDB; 1011236at2759; -.
DR Proteomes; UP000007305; Chromosome 3.
DR ExpressionAtlas; Q8W119; baseline and differential.
DR Genevisible; Q8W119; ZM.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; ISS:UniProtKB.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR044597; SMH1-6.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46267; PTHR46267; 1.
DR Pfam; PF00538; Linker_histone; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00526; H15; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51504; H15; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Coiled coil; DNA-binding; Nucleus; Reference proteome;
KW Telomere; Transcription; Transcription regulation.
FT CHAIN 1..288
FT /note="Single myb histone 4"
FT /id="PRO_0000429016"
FT DOMAIN 1..60
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 113..181
FT /note="H15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT DNA_BIND 28..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 230..250
FT /evidence="ECO:0000255"
FT COMPBIAS 7..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 179
FT /note="L -> I (in Ref. 1; AAQ62068)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 288 AA; 31336 MW; 008D2CD927FB769C CRC64;
MGAPKQKWTS EEEDALRAGV RKHGAGKWRT IQKDPEFSPV LSSRSNIDLK DKWRNLSFSA
SGLGSSKLRV PKITGPSSSP SSSSQPLLLP AANKFTEATL PADAEKKPQD GKTLPKYGAM
IMEALLELNE PNGSDIAAIF GFIEQRYAVQ PTFRRFLASK LRRLADSNKI EKIDKSYRLP
DSLATRTPAP MNASAPKQKD PSKPSKVSKA IGLFSASSPA LEAAMAAAVK VADAEAKAHD
AHDQTMEAER IFKMAEDTES LLIIAAEIYD RCSRGEITTL VPVAQREI
