SMH6_MAIZE
ID SMH6_MAIZE Reviewed; 317 AA.
AC C0HIA3; Q6WLH1;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Single myb histone 6;
DE AltName: Full=Protein SINGLE MYB HISTONE6;
GN Name=SMH6;
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. W23;
RX PubMed=14576282; DOI=10.1104/pp.103.026856;
RA Marian C.O., Bordoli S.J., Goltz M., Santarella R.A., Jackson L.P.,
RA Danilevskaya O., Beckstette M., Meeley R., Bass H.W.;
RT "The maize Single myb histone 1 gene, Smh1, belongs to a novel gene family
RT and encodes a protein that binds telomere DNA repeats in vitro.";
RL Plant Physiol. 133:1336-1350(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. B73;
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
CC -!- FUNCTION: Binds preferentially double-stranded telomeric repeats, but
CC may also bind to the single telomeric strand. {ECO:0000250}.
CC -!- SUBUNIT: Forms a homodimer and heterodimers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000255|PROSITE-ProRule:PRU00837}. Chromosome {ECO:0000255|PROSITE-
CC ProRule:PRU00837}. Nucleus, nucleolus {ECO:0000250}. Chromosome,
CC telomere {ECO:0000305}. Note=Localized to the nucleolus during
CC interphase. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=C0HIA3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=C0HIA3-2; Sequence=VSP_054626, VSP_054627;
CC -!- DOMAIN: HTH myb-type domain confers double-stranded telomeric DNA-
CC binding while the H15 domain is involved in non-specific DNA-protein
CC interaction and multimerization. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the histone H1/H5 family. SMH subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00837}.
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DR EMBL; AY280632; AAQ62069.1; -; mRNA.
DR EMBL; BT062059; ACN26756.1; -; mRNA.
DR RefSeq; NP_001105670.1; NM_001112200.1. [C0HIA3-2]
DR RefSeq; XP_008644292.1; XM_008646070.1. [C0HIA3-1]
DR AlphaFoldDB; C0HIA3; -.
DR SMR; C0HIA3; -.
DR STRING; 4577.GRMZM2G095239_P01; -.
DR PaxDb; C0HIA3; -.
DR PRIDE; C0HIA3; -.
DR EnsemblPlants; Zm00001eb218710_T005; Zm00001eb218710_P005; Zm00001eb218710. [C0HIA3-2]
DR GeneID; 542683; -.
DR Gramene; Zm00001eb218710_T005; Zm00001eb218710_P005; Zm00001eb218710. [C0HIA3-2]
DR KEGG; zma:542683; -.
DR eggNOG; ENOG502QSU2; Eukaryota.
DR OMA; TMNVHEA; -.
DR OrthoDB; 1324883at2759; -.
DR Proteomes; UP000007305; Chromosome 5.
DR ExpressionAtlas; C0HIA3; baseline and differential.
DR GO; GO:0000785; C:chromatin; ISS:UniProtKB.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; ISS:UniProtKB.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR044597; SMH1-6.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46267; PTHR46267; 1.
DR Pfam; PF00538; Linker_histone; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00526; H15; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51504; H15; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chromosome; Coiled coil; DNA-binding; Nucleus;
KW Reference proteome; Telomere; Transcription; Transcription regulation.
FT CHAIN 1..317
FT /note="Single myb histone 6"
FT /id="PRO_0000429018"
FT DOMAIN 1..61
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 121..189
FT /note="H15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT DNA_BIND 28..57
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT COILED 244..288
FT /evidence="ECO:0000255"
FT VAR_SEQ 297..298
FT /note="VI -> MA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14576282"
FT /id="VSP_054626"
FT VAR_SEQ 299..317
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14576282"
FT /id="VSP_054627"
SQ SEQUENCE 317 AA; 35174 MW; ED4E2F362FC0A6F9 CRC64;
MGAPKQRWTS EEEAALRAGI ARHGVGKWRT ILKDPEFSST LCYRSNVDLK DKWRNMNVIV
STSSSRDKAK SALKRIRTIP KNNEHTMAIT RVTSDIDDEI VDEKPIVSLP SEAKNTSSSK
KSHRLDNIIM EAIKNLNEPT GSHRTTIANY IEEQYWPPSD FDHLLSAKLK DLSTSGKLIK
VNRKYRIAPS SPNSERRSPK MPLLEDVQRE PVKIWSDDTK TLTRSQVDAE LARMATMTAE
EASVAAARAV AEAEAIMAEA EAAAKEAEAA EAEAQAAQAF AEAAFLTLKN RNAGKLVIAL
IHASLCYILP CFISYHI
