SMI19_HUMAN
ID SMI19_HUMAN Reviewed; 107 AA.
AC Q96E16; B2R4S6; D3DSY4;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Small integral membrane protein 19;
GN Name=SMIM19; Synonyms=C8orf40;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96E16; Q12797-6: ASPH; NbExp=3; IntAct=EBI-17657124, EBI-12092171;
CC Q96E16; O43681: GET3; NbExp=3; IntAct=EBI-17657124, EBI-2515857;
CC Q96E16; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-17657124, EBI-10266796;
CC Q96E16; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-17657124, EBI-741480;
CC Q96E16; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-17657124, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMIM19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH13035.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG34873.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK311932; BAG34873.1; ALT_INIT; mRNA.
DR EMBL; AC090739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471080; EAW63211.1; -; Genomic_DNA.
DR EMBL; CH471080; EAW63212.1; -; Genomic_DNA.
DR EMBL; BC013035; AAH13035.1; ALT_INIT; mRNA.
DR CCDS; CCDS6133.2; -.
DR RefSeq; NP_001129146.1; NM_001135674.1.
DR RefSeq; NP_001129147.1; NM_001135675.1.
DR RefSeq; NP_001129148.1; NM_001135676.1.
DR RefSeq; NP_612445.2; NM_138436.3.
DR AlphaFoldDB; Q96E16; -.
DR BioGRID; 125398; 6.
DR IntAct; Q96E16; 5.
DR STRING; 9606.ENSP00000391549; -.
DR iPTMnet; Q96E16; -.
DR PhosphoSitePlus; Q96E16; -.
DR BioMuta; SMIM19; -.
DR DMDM; 294862418; -.
DR EPD; Q96E16; -.
DR jPOST; Q96E16; -.
DR MassIVE; Q96E16; -.
DR MaxQB; Q96E16; -.
DR PaxDb; Q96E16; -.
DR PeptideAtlas; Q96E16; -.
DR PRIDE; Q96E16; -.
DR ProteomicsDB; 76364; -.
DR Antibodypedia; 2641; 69 antibodies from 12 providers.
DR DNASU; 114926; -.
DR Ensembl; ENST00000414154.6; ENSP00000408997.2; ENSG00000176209.12.
DR Ensembl; ENST00000416469.6; ENSP00000390750.2; ENSG00000176209.12.
DR Ensembl; ENST00000417410.7; ENSP00000405694.2; ENSG00000176209.12.
DR Ensembl; ENST00000438528.7; ENSP00000391549.2; ENSG00000176209.12.
DR Ensembl; ENST00000490331.2; ENSP00000429586.1; ENSG00000176209.12.
DR GeneID; 114926; -.
DR KEGG; hsa:114926; -.
DR MANE-Select; ENST00000417410.7; ENSP00000405694.2; NM_001135674.2; NP_001129146.1.
DR UCSC; uc003xpg.4; human.
DR CTD; 114926; -.
DR DisGeNET; 114926; -.
DR GeneCards; SMIM19; -.
DR HGNC; HGNC:25166; SMIM19.
DR HPA; ENSG00000176209; Low tissue specificity.
DR neXtProt; NX_Q96E16; -.
DR OpenTargets; ENSG00000176209; -.
DR PharmGKB; PA142672359; -.
DR VEuPathDB; HostDB:ENSG00000176209; -.
DR eggNOG; ENOG502S18T; Eukaryota.
DR GeneTree; ENSGT00390000000436; -.
DR HOGENOM; CLU_172229_0_0_1; -.
DR InParanoid; Q96E16; -.
DR OMA; XRKYDYQ; -.
DR OrthoDB; 1608152at2759; -.
DR PhylomeDB; Q96E16; -.
DR TreeFam; TF332548; -.
DR PathwayCommons; Q96E16; -.
DR SignaLink; Q96E16; -.
DR BioGRID-ORCS; 114926; 14 hits in 1076 CRISPR screens.
DR ChiTaRS; SMIM19; human.
DR GenomeRNAi; 114926; -.
DR Pharos; Q96E16; Tdark.
DR PRO; PR:Q96E16; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96E16; protein.
DR Bgee; ENSG00000176209; Expressed in parotid gland and 185 other tissues.
DR ExpressionAtlas; Q96E16; baseline and differential.
DR Genevisible; Q96E16; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029368; SMIM19.
DR PANTHER; PTHR31888; PTHR31888; 1.
DR Pfam; PF15117; UPF0697; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..107
FT /note="Small integral membrane protein 19"
FT /id="PRO_0000264626"
FT TRANSMEM 25..43
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 107 AA; 12439 MW; BC12D67B91DDD321 CRC64;
MAGGYGVMGD DGSIDYTVHE AWNEATNVYL IVILVSFGLF MYAKRNKRRI MRIFSVPPTE
ETLSEPNFYD TISKIRLRQQ LEMYSISRKY DYQQPQNQAD SVQLSLE
