SMI19_MOUSE
ID SMI19_MOUSE Reviewed; 107 AA.
AC Q80ZU4;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Small integral membrane protein 19;
GN Name=Smim19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMIM19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH48089.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE20860.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE21793.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE24529.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK131902; BAE20860.1; ALT_INIT; mRNA.
DR EMBL; AK133712; BAE21793.1; ALT_INIT; mRNA.
DR EMBL; AK140957; BAE24529.1; ALT_INIT; mRNA.
DR EMBL; BC048089; AAH48089.1; ALT_INIT; mRNA.
DR CCDS; CCDS52520.1; -.
DR RefSeq; NP_001012685.2; NM_001012667.2.
DR RefSeq; NP_001139589.1; NM_001146117.1.
DR AlphaFoldDB; Q80ZU4; -.
DR STRING; 10090.ENSMUSP00000131855; -.
DR iPTMnet; Q80ZU4; -.
DR PhosphoSitePlus; Q80ZU4; -.
DR MaxQB; Q80ZU4; -.
DR PaxDb; Q80ZU4; -.
DR PRIDE; Q80ZU4; -.
DR ProteomicsDB; 261434; -.
DR Antibodypedia; 2641; 69 antibodies from 12 providers.
DR DNASU; 102032; -.
DR Ensembl; ENSMUST00000033935; ENSMUSP00000033935; ENSMUSG00000031534.
DR GeneID; 102032; -.
DR KEGG; mmu:102032; -.
DR UCSC; uc009lde.2; mouse.
DR CTD; 114926; -.
DR MGI; MGI:2142501; Smim19.
DR VEuPathDB; HostDB:ENSMUSG00000031534; -.
DR eggNOG; ENOG502S18T; Eukaryota.
DR GeneTree; ENSGT00390000000436; -.
DR HOGENOM; CLU_172229_0_0_1; -.
DR InParanoid; Q80ZU4; -.
DR OrthoDB; 1608152at2759; -.
DR PhylomeDB; Q80ZU4; -.
DR BioGRID-ORCS; 102032; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Smim19; mouse.
DR PRO; PR:Q80ZU4; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q80ZU4; protein.
DR Bgee; ENSMUSG00000031534; Expressed in interventricular septum and 246 other tissues.
DR ExpressionAtlas; Q80ZU4; baseline and differential.
DR Genevisible; Q80ZU4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029368; SMIM19.
DR PANTHER; PTHR31888; PTHR31888; 1.
DR Pfam; PF15117; UPF0697; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..107
FT /note="Small integral membrane protein 19"
FT /id="PRO_0000264627"
FT TRANSMEM 25..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 88..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 107 AA; 12283 MW; F7D6AC9E124CA2A7 CRC64;
MAGSYGVMAD DGSIDYTVHE AWNEATNVYL IVILVSFGLF MYAKRNKRKI MRIFSVPPTE
GMLSEPSFYD TVSRIRLRQQ VEAHPVSRKY EYQQPQSQAD SVQLSLE
