ID   SMI1_KLULA              Reviewed;         535 AA.
AC   Q6CN28;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=KNR4/SMI1 homolog;
GN   OrderedLocusNames=KLLA0E15862g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SIMILARITY: Belongs to the KNR4/SMI1 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99748.1; -; Genomic_DNA.
DR   RefSeq; XP_454661.1; XM_454661.1.
DR   AlphaFoldDB; Q6CN28; -.
DR   SMR; Q6CN28; -.
DR   STRING; 28985.XP_454661.1; -.
DR   EnsemblFungi; CAG99748; CAG99748; KLLA0_E15775g.
DR   GeneID; 2894575; -.
DR   KEGG; kla:KLLA0_E15775g; -.
DR   eggNOG; ENOG502QTAZ; Eukaryota.
DR   HOGENOM; CLU_027501_3_0_1; -.
DR   InParanoid; Q6CN28; -.
DR   OMA; HEQNEST; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005935; C:cellular bud neck; IEA:EnsemblFungi.
DR   GO; GO:0000131; C:incipient cellular bud site; IEA:EnsemblFungi.
DR   GO; GO:0042546; P:cell wall biogenesis; IEA:InterPro.
DR   GO; GO:0032995; P:regulation of fungal-type cell wall biogenesis; IEA:EnsemblFungi.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:EnsemblFungi.
DR   Gene3D; 3.40.1580.10; -; 1.
DR   InterPro; IPR009203; Knr4/Smi1.
DR   InterPro; IPR018958; Knr4/Smi1-like_dom.
DR   InterPro; IPR037883; Knr4/Smi1-like_sf.
DR   Pfam; PF09346; SMI1_KNR4; 1.
DR   PIRSF; PIRSF017023; KNR4; 1.
DR   SMART; SM00860; SMI1_KNR4; 1.
DR   SUPFAM; SSF160631; SSF160631; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..535
FT                   /note="KNR4/SMI1 homolog"
FT                   /id="PRO_0000209876"
FT   REGION          354..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        415..430
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..471
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..535
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   535 AA;  59748 MW;  6FAAF06760435BA6 CRC64;
     MQAFKKKLQQ LVYSFSTEDR YADYDEEAAN PDVAAGVERS ITESNHGSQI QLADYVDGSN
     PSGNEGINEA LLAWRHIDNW TSQHNPDLAA TLSDPCTRHD INNAEKDLDI IFPASVRASL
     RLHDGQEDLV SMTGTGGLFF GLQLMGLDEI VQMTRTWRNV AENLERKNHE LQIKMDKHQE
     LNGTTVDLPN QQKGYGKLEN QDYKAMDPNL QRNISQNYKK QFKLPDIPDQ HSVPPLAIQQ
     VYANSGWIPL VTDNAGNHIG IDLAPGPKGK YGQVILFGRE FDTKFVVASN WGDFLLSFAN
     DLELGNWLLI DEGNDQFAGE GELVFRDKKS NGPVRDYLEV LVMRSRMKWN SFTERKLPEE
     PKRTVSSSQG SQNTVEPAEQ QETALTVDET LDEKNDTSLS VDNTGTKQEV KDPETTGTKT
     GSSAKAEDNL PKTSNPDEVM ADGADTQETS KHEQNESTNA VENTETSQEG AVETSEKPEE
     KPKKQSKKAS KKKGKKDEKK DTDSKTKEPE VEEETESHLA NSVEKLKDDF ENVAL