ID   SMI21_HUMAN             Reviewed;         101 AA.
AC   Q3B7S5;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Small integral membrane protein 21;
GN   Name=SMIM21; Synonyms=C18orf62;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q3B7S5; Q6ICB0: DESI1; NbExp=3; IntAct=EBI-23836218, EBI-2806959;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC107486; AAI07487.1; -; mRNA.
DR   CCDS; CCDS32845.1; -.
DR   RefSeq; NP_001032408.1; NM_001037331.3.
DR   AlphaFoldDB; Q3B7S5; -.
DR   BioGRID; 129814; 2.
DR   IntAct; Q3B7S5; 1.
DR   STRING; 9606.ENSP00000462106; -.
DR   BioMuta; SMIM21; -.
DR   PaxDb; Q3B7S5; -.
DR   PRIDE; Q3B7S5; -.
DR   Antibodypedia; 49144; 9 antibodies from 6 providers.
DR   DNASU; 284274; -.
DR   Ensembl; ENST00000579022.5; ENSP00000462106.1; ENSG00000206026.7.
DR   GeneID; 284274; -.
DR   KEGG; hsa:284274; -.
DR   MANE-Select; ENST00000579022.5; ENSP00000462106.1; NM_001037331.3; NP_001032408.1.
DR   UCSC; uc002lma.2; human.
DR   CTD; 284274; -.
DR   DisGeNET; 284274; -.
DR   GeneCards; SMIM21; -.
DR   HGNC; HGNC:27598; SMIM21.
DR   HPA; ENSG00000206026; Tissue enriched (testis).
DR   neXtProt; NX_Q3B7S5; -.
DR   OpenTargets; ENSG00000206026; -.
DR   PharmGKB; PA162378613; -.
DR   VEuPathDB; HostDB:ENSG00000206026; -.
DR   eggNOG; ENOG502TEQP; Eukaryota.
DR   GeneTree; ENSGT00940000166968; -.
DR   HOGENOM; CLU_2497188_0_0_1; -.
DR   InParanoid; Q3B7S5; -.
DR   OrthoDB; 1560994at2759; -.
DR   PhylomeDB; Q3B7S5; -.
DR   PathwayCommons; Q3B7S5; -.
DR   SignaLink; Q3B7S5; -.
DR   BioGRID-ORCS; 284274; 11 hits in 1057 CRISPR screens.
DR   ChiTaRS; SMIM21; human.
DR   GenomeRNAi; 284274; -.
DR   Pharos; Q3B7S5; Tdark.
DR   PRO; PR:Q3B7S5; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; Q3B7S5; protein.
DR   Bgee; ENSG00000206026; Expressed in sperm and 5 other tissues.
DR   ExpressionAtlas; Q3B7S5; baseline and differential.
DR   Genevisible; Q3B7S5; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..101
FT                   /note="Small integral membrane protein 21"
FT                   /id="PRO_0000340722"
FT   TRANSMEM        49..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   101 AA;  11722 MW;  82E93FA8AFB9C6C7 CRC64;
     MDQYVSTAPP RFPIAQLGTF KQDSAGMGRI FKGNLLQKKA LTTFENEHHI RFFTLLVLFH
     VMVLLRNHSR IQGVSEDWKR ANSIFRNFLR LKSSRNTAEA E