SMIM2_HUMAN
ID SMIM2_HUMAN Reviewed; 85 AA.
AC Q9BVW6; Q5SZS7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Small integral membrane protein 2;
GN Name=SMIM2; Synonyms=C13orf44;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BVW6; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-10300146, EBI-741480;
CC Q9BVW6; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-10300146, EBI-10173939;
CC Q9BVW6; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-10300146, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL589745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08705.1; -; Genomic_DNA.
DR EMBL; BC000868; AAH00868.1; -; mRNA.
DR CCDS; CCDS61320.1; -.
DR RefSeq; NP_076963.1; NM_024058.2.
DR AlphaFoldDB; Q9BVW6; -.
DR BioGRID; 122492; 2.
DR IntAct; Q9BVW6; 2.
DR STRING; 9606.ENSP00000383270; -.
DR TCDB; 1.A.124.1.1; the small mitochondrial integral membrane protein (smim) family.
DR iPTMnet; Q9BVW6; -.
DR PhosphoSitePlus; Q9BVW6; -.
DR BioMuta; SMIM2; -.
DR PaxDb; Q9BVW6; -.
DR PeptideAtlas; Q9BVW6; -.
DR PRIDE; Q9BVW6; -.
DR Antibodypedia; 23547; 6 antibodies from 6 providers.
DR DNASU; 79024; -.
DR Ensembl; ENST00000400419.2; ENSP00000383270.1; ENSG00000139656.7.
DR Ensembl; ENST00000617002.1; ENSP00000483761.1; ENSG00000139656.7.
DR GeneID; 79024; -.
DR KEGG; hsa:79024; -.
DR MANE-Select; ENST00000400419.2; ENSP00000383270.1; NM_024058.3; NP_076963.1.
DR UCSC; uc001uzh.3; human.
DR CTD; 79024; -.
DR GeneCards; SMIM2; -.
DR HGNC; HGNC:28776; SMIM2.
DR HPA; ENSG00000139656; Tissue enriched (testis).
DR neXtProt; NX_Q9BVW6; -.
DR OpenTargets; ENSG00000139656; -.
DR VEuPathDB; HostDB:ENSG00000139656; -.
DR eggNOG; ENOG502TFJG; Eukaryota.
DR GeneTree; ENSGT00390000014262; -.
DR HOGENOM; CLU_2512005_0_0_1; -.
DR InParanoid; Q9BVW6; -.
DR OMA; DEPHARI; -.
DR OrthoDB; 1626206at2759; -.
DR PhylomeDB; Q9BVW6; -.
DR TreeFam; TF340934; -.
DR PathwayCommons; Q9BVW6; -.
DR SignaLink; Q9BVW6; -.
DR BioGRID-ORCS; 79024; 4 hits in 930 CRISPR screens.
DR Pharos; Q9BVW6; Tdark.
DR PRO; PR:Q9BVW6; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q9BVW6; protein.
DR Bgee; ENSG00000139656; Expressed in left testis and 106 other tissues.
DR Genevisible; Q9BVW6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..85
FT /note="Small integral membrane protein 2"
FT /id="PRO_0000318960"
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 51..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 85 AA; 9520 MW; 2E5D15FC44C090FE CRC64;
MEAGERIDAS QLPHRVLETR GHAISILFGF WTSFICDTYI VLAWISKIKG SPDVSASSDE
PYARIQQSRR QCHAEEDQSQ VPEAG
