SMIM3_HUMAN
ID SMIM3_HUMAN Reviewed; 60 AA.
AC Q9BZL3; Q3MIG3; Q6ZUV4;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Small integral membrane protein 3;
DE AltName: Full=NGF-induced differentiation clone 67 protein;
DE AltName: Full=Small membrane protein NID67;
GN Name=SMIM3; Synonyms=C5orf62, NID67;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Colon;
RX PubMed=11288140; DOI=10.1002/jnr.1058;
RA Vician L., Silver A.L., Farias-Eisner R., Herschman H.R.;
RT "NID67, a small putative membrane protein, is preferentially induced by NGF
RT in PC12 pheochromocytoma cells.";
RL J. Neurosci. Res. 64:108-120(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neuroblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BZL3; P07307-3: ASGR2; NbExp=3; IntAct=EBI-741850, EBI-12808270;
CC Q9BZL3; Q9UN42: ATP1B4; NbExp=3; IntAct=EBI-741850, EBI-12894731;
CC Q9BZL3; P27449: ATP6V0C; NbExp=6; IntAct=EBI-741850, EBI-721179;
CC Q9BZL3; Q12983: BNIP3; NbExp=3; IntAct=EBI-741850, EBI-749464;
CC Q9BZL3; J3KQ12: BSCL2; NbExp=6; IntAct=EBI-741850, EBI-11532900;
CC Q9BZL3; Q96G97: BSCL2; NbExp=4; IntAct=EBI-741850, EBI-741806;
CC Q9BZL3; Q96G97-4: BSCL2; NbExp=3; IntAct=EBI-741850, EBI-10178113;
CC Q9BZL3; Q6UXG8-3: BTNL9; NbExp=3; IntAct=EBI-741850, EBI-17953245;
CC Q9BZL3; P19397: CD53; NbExp=3; IntAct=EBI-741850, EBI-6657396;
CC Q9BZL3; P11912: CD79A; NbExp=3; IntAct=EBI-741850, EBI-7797864;
CC Q9BZL3; P27701: CD82; NbExp=3; IntAct=EBI-741850, EBI-682379;
CC Q9BZL3; O75508: CLDN11; NbExp=3; IntAct=EBI-741850, EBI-12820543;
CC Q9BZL3; O00501: CLDN5; NbExp=3; IntAct=EBI-741850, EBI-18400628;
CC Q9BZL3; P56748: CLDN8; NbExp=3; IntAct=EBI-741850, EBI-10215641;
CC Q9BZL3; Q6ZS10: CLEC17A; NbExp=6; IntAct=EBI-741850, EBI-11977093;
CC Q9BZL3; Q9BXN2: CLEC7A; NbExp=3; IntAct=EBI-741850, EBI-3939278;
CC Q9BZL3; Q9BXN2-6: CLEC7A; NbExp=4; IntAct=EBI-741850, EBI-11989440;
CC Q9BZL3; O95406: CNIH1; NbExp=6; IntAct=EBI-741850, EBI-12172273;
CC Q9BZL3; Q8TBE1: CNIH3; NbExp=5; IntAct=EBI-741850, EBI-12208021;
CC Q9BZL3; Q15125: EBP; NbExp=3; IntAct=EBI-741850, EBI-3915253;
CC Q9BZL3; P54849: EMP1; NbExp=6; IntAct=EBI-741850, EBI-4319440;
CC Q9BZL3; P54852: EMP3; NbExp=3; IntAct=EBI-741850, EBI-3907816;
CC Q9BZL3; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-741850, EBI-781551;
CC Q9BZL3; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-741850, EBI-12142257;
CC Q9BZL3; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-741850, EBI-6166686;
CC Q9BZL3; O15529: GPR42; NbExp=3; IntAct=EBI-741850, EBI-18076404;
CC Q9BZL3; P38484: IFNGR2; NbExp=3; IntAct=EBI-741850, EBI-3905457;
CC Q9BZL3; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-741850, EBI-17272405;
CC Q9BZL3; P43657: LPAR6; NbExp=3; IntAct=EBI-741850, EBI-2876949;
CC Q9BZL3; Q8N112: LSMEM2; NbExp=3; IntAct=EBI-741850, EBI-10264855;
CC Q9BZL3; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-741850, EBI-741037;
CC Q9BZL3; P21145: MAL; NbExp=6; IntAct=EBI-741850, EBI-3932027;
CC Q9BZL3; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-741850, EBI-12806656;
CC Q9BZL3; Q9BQ51: PDCD1LG2; NbExp=3; IntAct=EBI-741850, EBI-16427978;
CC Q9BZL3; P60201-2: PLP1; NbExp=4; IntAct=EBI-741850, EBI-12188331;
CC Q9BZL3; Q01453: PMP22; NbExp=9; IntAct=EBI-741850, EBI-2845982;
CC Q9BZL3; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-741850, EBI-302345;
CC Q9BZL3; Q9NS64: RPRM; NbExp=3; IntAct=EBI-741850, EBI-1052363;
CC Q9BZL3; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-741850, EBI-8652744;
CC Q9BZL3; P11686: SFTPC; NbExp=4; IntAct=EBI-741850, EBI-10197617;
CC Q9BZL3; Q16585: SGCB; NbExp=3; IntAct=EBI-741850, EBI-5663627;
CC Q9BZL3; Q08AT0: SGCZ; NbExp=3; IntAct=EBI-741850, EBI-12877338;
CC Q9BZL3; O15245: SLC22A1; NbExp=3; IntAct=EBI-741850, EBI-1172714;
CC Q9BZL3; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-741850, EBI-9978441;
CC Q9BZL3; Q9NRQ5: SMCO4; NbExp=5; IntAct=EBI-741850, EBI-8640191;
CC Q9BZL3; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-741850, EBI-741850;
CC Q9BZL3; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-741850, EBI-17498703;
CC Q9BZL3; Q16623: STX1A; NbExp=3; IntAct=EBI-741850, EBI-712466;
CC Q9BZL3; Q9Y6I9: TEX264; NbExp=3; IntAct=EBI-741850, EBI-10329860;
CC Q9BZL3; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-741850, EBI-13351685;
CC Q9BZL3; Q6ZP80: TMEM182; NbExp=3; IntAct=EBI-741850, EBI-10255122;
CC Q9BZL3; A2RU14: TMEM218; NbExp=3; IntAct=EBI-741850, EBI-10173151;
CC Q9BZL3; O95159: ZFPL1; NbExp=5; IntAct=EBI-741850, EBI-718439;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: By NGF.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI01839.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=AAI01841.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=AAI06041.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=BAC86114.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=EAW61705.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF313413; AAG53959.1; -; mRNA.
DR EMBL; AK125286; BAC86114.1; ALT_SEQ; mRNA.
DR EMBL; AC010441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471062; EAW61705.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC009719; AAH09719.1; -; mRNA.
DR EMBL; BC101838; AAI01839.1; ALT_SEQ; mRNA.
DR EMBL; BC101840; AAI01841.1; ALT_SEQ; mRNA.
DR EMBL; BC106040; AAI06041.1; ALT_SEQ; mRNA.
DR CCDS; CCDS47312.2; -.
DR RefSeq; NP_116565.3; NM_032947.4.
DR AlphaFoldDB; Q9BZL3; -.
DR SMR; Q9BZL3; -.
DR BioGRID; 124436; 53.
DR IntAct; Q9BZL3; 50.
DR STRING; 9606.ENSP00000436897; -.
DR GlyConnect; 2929; 2 O-Linked glycans (1 site).
DR BioMuta; SMIM3; -.
DR PaxDb; Q9BZL3; -.
DR PeptideAtlas; Q9BZL3; -.
DR PRIDE; Q9BZL3; -.
DR Antibodypedia; 71669; 4 antibodies from 4 providers.
DR DNASU; 85027; -.
DR Ensembl; ENST00000526627.2; ENSP00000436897.1; ENSG00000256235.3.
DR Ensembl; ENST00000648745.1; ENSP00000496958.1; ENSG00000256235.3.
DR GeneID; 85027; -.
DR KEGG; hsa:85027; -.
DR MANE-Select; ENST00000526627.2; ENSP00000436897.1; NM_032947.5; NP_116565.3.
DR UCSC; uc003lsw.4; human.
DR CTD; 85027; -.
DR GeneCards; SMIM3; -.
DR HGNC; HGNC:30248; SMIM3.
DR HPA; ENSG00000256235; Tissue enhanced (adipose).
DR MIM; 608324; gene.
DR neXtProt; NX_Q9BZL3; -.
DR OpenTargets; ENSG00000256235; -.
DR PharmGKB; PA165660222; -.
DR VEuPathDB; HostDB:ENSG00000256235; -.
DR eggNOG; ENOG502SGSH; Eukaryota.
DR GeneTree; ENSGT00390000009443; -.
DR HOGENOM; CLU_2941125_0_0_1; -.
DR InParanoid; Q9BZL3; -.
DR OMA; YRIRTHP; -.
DR PhylomeDB; Q9BZL3; -.
DR TreeFam; TF354124; -.
DR PathwayCommons; Q9BZL3; -.
DR SignaLink; Q9BZL3; -.
DR BioGRID-ORCS; 85027; 36 hits in 1070 CRISPR screens.
DR ChiTaRS; SMIM3; human.
DR GenomeRNAi; 85027; -.
DR Pharos; Q9BZL3; Tdark.
DR PRO; PR:Q9BZL3; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9BZL3; protein.
DR Bgee; ENSG00000256235; Expressed in adipose tissue of abdominal region and 146 other tissues.
DR Genevisible; Q9BZL3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR035275; Smim3.
DR PANTHER; PTHR37859; PTHR37859; 1.
DR Pfam; PF17307; Smim3; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..60
FT /note="Small integral membrane protein 3"
FT /id="PRO_0000096816"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT SITE 19..20
FT /note="Cleavage"
FT /evidence="ECO:0000250|UniProtKB:Q99PE6"
SQ SEQUENCE 60 AA; 6593 MW; FEE7DA7A6E02B08E CRC64;
MDAVSQVPME VVLPKHILDI WVIVLIILAT IVIMTSLLLC PATAVIIYRM RTHPILSGAV
