ID   BIN3_RAT                Reviewed;         253 AA.
AC   Q68FW8;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Bridging integrator 3;
GN   Name=Bin3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in cytokinesis and septation where it has a role in
CC       the localization of F-actin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC079146; AAH79146.1; -; mRNA.
DR   RefSeq; NP_001013204.1; NM_001013186.1.
DR   AlphaFoldDB; Q68FW8; -.
DR   SMR; Q68FW8; -.
DR   STRING; 10116.ENSRNOP00000024614; -.
DR   PaxDb; Q68FW8; -.
DR   DNASU; 361065; -.
DR   Ensembl; ENSRNOT00000024614; ENSRNOP00000024614; ENSRNOG00000018023.
DR   GeneID; 361065; -.
DR   KEGG; rno:361065; -.
DR   UCSC; RGD:1308253; rat.
DR   CTD; 55909; -.
DR   RGD; 1308253; Bin3.
DR   eggNOG; KOG3771; Eukaryota.
DR   GeneTree; ENSGT00950000182882; -.
DR   HOGENOM; CLU_090113_1_0_1; -.
DR   InParanoid; Q68FW8; -.
DR   OMA; TRFCAYF; -.
DR   OrthoDB; 1172471at2759; -.
DR   PhylomeDB; Q68FW8; -.
DR   PRO; PR:Q68FW8; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000018023; Expressed in spleen and 20 other tissues.
DR   ExpressionAtlas; Q68FW8; baseline and differential.
DR   GO; GO:0015629; C:actin cytoskeleton; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0051666; P:actin cortical patch localization; IBA:GO_Central.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0014839; P:myoblast migration involved in skeletal muscle regeneration; ISO:RGD.
DR   GO; GO:0097320; P:plasma membrane tubulation; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; ISO:RGD.
DR   GO; GO:0010591; P:regulation of lamellipodium assembly; ISO:RGD.
DR   GO; GO:0048741; P:skeletal muscle fiber development; ISO:RGD.
DR   GO; GO:0043403; P:skeletal muscle tissue regeneration; ISO:RGD.
DR   GO; GO:0009826; P:unidimensional cell growth; ISO:RGD.
DR   CDD; cd07590; BAR_Bin3; 1.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR037428; Bin3_BAR.
DR   Pfam; PF03114; BAR; 1.
DR   SMART; SM00721; BAR; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   PROSITE; PS51021; BAR; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome; Septation.
FT   CHAIN           1..253
FT                   /note="Bridging integrator 3"
FT                   /id="PRO_0000192957"
FT   DOMAIN          9..232
FT                   /note="BAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT   COILED          16..57
FT                   /evidence="ECO:0000255"
FT   COILED          120..151
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   253 AA;  29691 MW;  5C4C6BF5AA8A8EDD CRC64;
     MSWIPFKIGQ PKKQIVSKTV ERDFEREYGK LQQLEEQTKR LQKDMKKSTD ADLAMSKSAV
     KISLDLLSNP LCEQDQDFLR MVTALDTAMK RMDAFNQEKV NQIQKTVIEP LKKFGSIFPS
     LNMAVKRREQ ALQDYGRLQA KVEKYEEKEK TGPVLAKLHQ AREELRPVRE DFEAKNKQLL
     DEMPRFYNSR LDYFQPSFES LIRAQVIYYS EMHKIFGDLT QQLDQPGHSD EHRERENETK
     LSELRALSIV ADD