SMIM5_HUMAN
ID SMIM5_HUMAN Reviewed; 77 AA.
AC Q71RC9;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Small integral membrane protein 5;
GN Name=SMIM5; Synonyms=C17orf109;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang Y., Zhou X.M., Zhang P.P., Jiang H.Q., Qin W.X., Zhao X.T., Wan D.F.,
RA Gu J.R.;
RT "Novel human cDNA clones with function of inhibiting cancer cell growth.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q71RC9; P53367: ARFIP1; NbExp=3; IntAct=EBI-12334905, EBI-2808808;
CC Q71RC9; Q08426: EHHADH; NbExp=3; IntAct=EBI-12334905, EBI-2339219;
CC Q71RC9; Q7Z6L0: PRRT2; NbExp=3; IntAct=EBI-12334905, EBI-722696;
CC Q71RC9; Q8N0V3: RBFA; NbExp=3; IntAct=EBI-12334905, EBI-3232108;
CC Q71RC9; O43765: SGTA; NbExp=9; IntAct=EBI-12334905, EBI-347996;
CC Q71RC9; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-12334905, EBI-2623095;
CC Q71RC9; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-12334905, EBI-2849569;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ15244.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=EAW89296.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF370408; AAQ15244.1; ALT_SEQ; mRNA.
DR EMBL; AC087749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471099; EAW89296.1; ALT_SEQ; Genomic_DNA.
DR CCDS; CCDS54165.1; -.
DR RefSeq; NP_001156467.1; NM_001162995.2.
DR RefSeq; XP_011523420.1; XM_011525118.2.
DR RefSeq; XP_011523421.1; XM_011525119.2.
DR RefSeq; XP_016880435.1; XM_017024946.1.
DR RefSeq; XP_016880436.1; XM_017024947.1.
DR RefSeq; XP_016880437.1; XM_017024948.1.
DR AlphaFoldDB; Q71RC9; -.
DR SMR; Q71RC9; -.
DR BioGRID; 568424; 69.
DR IntAct; Q71RC9; 7.
DR STRING; 9606.ENSP00000477017; -.
DR BioMuta; SMIM5; -.
DR DMDM; 338817840; -.
DR MassIVE; Q71RC9; -.
DR PaxDb; Q71RC9; -.
DR PeptideAtlas; Q71RC9; -.
DR PRIDE; Q71RC9; -.
DR ProteomicsDB; 68614; -.
DR Antibodypedia; 76985; 29 antibodies from 5 providers.
DR DNASU; 643008; -.
DR Ensembl; ENST00000375215.3; ENSP00000364363.3; ENSG00000204323.5.
DR Ensembl; ENST00000537494.1; ENSP00000477017.1; ENSG00000204323.5.
DR GeneID; 643008; -.
DR KEGG; hsa:643008; -.
DR MANE-Select; ENST00000375215.3; ENSP00000364363.3; NM_001162995.3; NP_001156467.1.
DR UCSC; uc002jow.3; human.
DR CTD; 643008; -.
DR DisGeNET; 643008; -.
DR GeneCards; SMIM5; -.
DR HGNC; HGNC:40030; SMIM5.
DR HPA; ENSG00000204323; Tissue enhanced (esophagus, kidney).
DR neXtProt; NX_Q71RC9; -.
DR OpenTargets; ENSG00000204323; -.
DR VEuPathDB; HostDB:ENSG00000204323; -.
DR eggNOG; ENOG502S8TU; Eukaryota.
DR GeneTree; ENSGT00520000062027; -.
DR HOGENOM; CLU_2644314_0_0_1; -.
DR InParanoid; Q71RC9; -.
DR OMA; HCCCCGK; -.
DR OrthoDB; 1633768at2759; -.
DR TreeFam; TF330807; -.
DR PathwayCommons; Q71RC9; -.
DR SignaLink; Q71RC9; -.
DR BioGRID-ORCS; 643008; 26 hits in 1030 CRISPR screens.
DR ChiTaRS; SMIM5; human.
DR GenomeRNAi; 643008; -.
DR Pharos; Q71RC9; Tdark.
DR PRO; PR:Q71RC9; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q71RC9; protein.
DR Bgee; ENSG00000204323; Expressed in pancreatic ductal cell and 137 other tissues.
DR Genevisible; Q71RC9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031671; DUF4713.
DR Pfam; PF15831; DUF4713; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..77
FT /note="Small integral membrane protein 5"
FT /id="PRO_0000410867"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 77 AA; 8540 MW; 7CC220E16930C30A CRC64;
MAATDFVQEM RAVGERLLLK LQRLPQAEPV EIVAFSVIIL FTATVLLLLL IACSCCCTHC
CCPERRGRKV QVQPTPP
