ID   SMIM5_MOUSE             Reviewed;          78 AA.
AC   Q8BT42;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Small integral membrane protein 5;
GN   Name=Smim5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AK004370; BAE43175.1; -; mRNA.
DR   EMBL; AK020450; BAC25633.1; -; mRNA.
DR   CCDS; CCDS70347.1; -.
DR   RefSeq; NP_899082.1; NM_183259.3.
DR   RefSeq; XP_006534006.1; XM_006533943.3.
DR   AlphaFoldDB; Q8BT42; -.
DR   SMR; Q8BT42; -.
DR   STRING; 10090.ENSMUSP00000139148; -.
DR   MaxQB; Q8BT42; -.
DR   PRIDE; Q8BT42; -.
DR   ProteomicsDB; 257206; -.
DR   Antibodypedia; 76985; 29 antibodies from 5 providers.
DR   Ensembl; ENSMUST00000142089; ENSMUSP00000138928; ENSMUSG00000048442.
DR   Ensembl; ENSMUST00000152171; ENSMUSP00000139148; ENSMUSG00000048442.
DR   GeneID; 66528; -.
DR   KEGG; mmu:66528; -.
DR   UCSC; uc007mja.2; mouse.
DR   CTD; 643008; -.
DR   MGI; MGI:1913778; Smim5.
DR   VEuPathDB; HostDB:ENSMUSG00000048442; -.
DR   eggNOG; ENOG502S8TU; Eukaryota.
DR   GeneTree; ENSGT00520000062027; -.
DR   HOGENOM; CLU_2644314_0_0_1; -.
DR   InParanoid; Q8BT42; -.
DR   OMA; HCCCCGK; -.
DR   OrthoDB; 1633768at2759; -.
DR   BioGRID-ORCS; 66528; 2 hits in 66 CRISPR screens.
DR   PRO; PR:Q8BT42; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8BT42; protein.
DR   Bgee; ENSMUSG00000048442; Expressed in otolith organ and 113 other tissues.
DR   ExpressionAtlas; Q8BT42; baseline and differential.
DR   Genevisible; Q8BT42; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031671; DUF4713.
DR   Pfam; PF15831; DUF4713; 1.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..78
FT                   /note="Small integral membrane protein 5"
FT                   /id="PRO_0000410868"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   78 AA;  8529 MW;  77E5FB74C1BE07BC CRC64;
     MAATDFVGEI RSVGERLLLK LQQLPQAEPV ELVAFSIIVL FTATVLVLGL IACSCCCAHC
     CCSESRQRKI PVRPTKPR