ID   SMIM6_HUMAN             Reviewed;          62 AA.
AC   P0DI80;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Small integral membrane protein 6;
GN   Name=SMIM6; Synonyms=C17orf110;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AK131023; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC087749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS54166.1; -.
DR   RefSeq; NP_001156469.1; NM_001162997.1.
DR   RefSeq; XP_005256960.1; XM_005256903.4.
DR   AlphaFoldDB; P0DI80; -.
DR   SMR; P0DI80; -.
DR   STRING; 9606.ENSP00000463361; -.
DR   TCDB; 1.A.113.5.1; the small integral membrane protein (simp) family.
DR   BioMuta; SMIM6; -.
DR   PaxDb; P0DI80; -.
DR   PeptideAtlas; P0DI80; -.
DR   PRIDE; P0DI80; -.
DR   Antibodypedia; 74683; 4 antibodies from 4 providers.
DR   DNASU; 100130933; -.
DR   Ensembl; ENST00000556126.2; ENSP00000450581.2; ENSG00000259120.3.
DR   Ensembl; ENST00000579469.2; ENSP00000463361.1; ENSG00000259120.3.
DR   GeneID; 100130933; -.
DR   KEGG; hsa:100130933; -.
DR   MANE-Select; ENST00000579469.2; ENSP00000463361.1; NM_001162997.2; NP_001156469.1.
DR   UCSC; uc002joy.4; human.
DR   CTD; 100130933; -.
DR   DisGeNET; 100130933; -.
DR   GeneCards; SMIM6; -.
DR   HGNC; HGNC:40032; SMIM6.
DR   HPA; ENSG00000259120; Tissue enhanced (fallopian tube, kidney, stomach, testis).
DR   neXtProt; NX_P0DI80; -.
DR   OpenTargets; ENSG00000259120; -.
DR   VEuPathDB; HostDB:ENSG00000259120; -.
DR   eggNOG; ENOG502RWMW; Eukaryota.
DR   GeneTree; ENSGT00940000165228; -.
DR   HOGENOM; CLU_210527_0_0_1; -.
DR   InParanoid; P0DI80; -.
DR   OMA; EFWQNPW; -.
DR   OrthoDB; 1639983at2759; -.
DR   PhylomeDB; P0DI80; -.
DR   PathwayCommons; P0DI80; -.
DR   BioGRID-ORCS; 100130933; 33 hits in 1053 CRISPR screens.
DR   Pharos; P0DI80; Tdark.
DR   PRO; PR:P0DI80; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P0DI80; protein.
DR   Bgee; ENSG00000259120; Expressed in sperm and 114 other tissues.
DR   Genevisible; P0DI80; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..62
FT                   /note="Small integral membrane protein 6"
FT                   /id="PRO_0000412225"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   62 AA;  7017 MW;  CA605EB69C41AD08 CRC64;
     MDQLVFKETI WNDAFWQNPW DQGGLAVIIL FITAVLLLIL FAIVFGLLTS TENTQCEAGE
     EE