SMIM7_HUMAN
ID SMIM7_HUMAN Reviewed; 75 AA.
AC Q9BQ49; A8MX44;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Small integral membrane protein 7;
DE Flags: Precursor;
GN Name=SMIM7; Synonyms=C19orf42;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hepatoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 62-75.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMIM7 family. {ECO:0000305}.
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DR EMBL; AK025602; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC024075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC001680; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC001948; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS12348.2; -.
DR RefSeq; NP_077009.2; NM_024104.3.
DR AlphaFoldDB; Q9BQ49; -.
DR BioGRID; 122534; 3.
DR IntAct; Q9BQ49; 2.
DR MINT; Q9BQ49; -.
DR STRING; 9606.ENSP00000351569; -.
DR iPTMnet; Q9BQ49; -.
DR PhosphoSitePlus; Q9BQ49; -.
DR SwissPalm; Q9BQ49; -.
DR BioMuta; SMIM7; -.
DR DMDM; 193806332; -.
DR EPD; Q9BQ49; -.
DR jPOST; Q9BQ49; -.
DR MassIVE; Q9BQ49; -.
DR MaxQB; Q9BQ49; -.
DR PaxDb; Q9BQ49; -.
DR PeptideAtlas; Q9BQ49; -.
DR PRIDE; Q9BQ49; -.
DR ProteomicsDB; 78621; -.
DR TopDownProteomics; Q9BQ49; -.
DR Antibodypedia; 27426; 17 antibodies from 8 providers.
DR DNASU; 79086; -.
DR Ensembl; ENST00000481671.6; ENSP00000433833.1; ENSG00000214046.9.
DR Ensembl; ENST00000487416.7; ENSP00000417147.1; ENSG00000214046.9.
DR Ensembl; ENST00000593404.5; ENSP00000471355.1; ENSG00000214046.9.
DR Ensembl; ENST00000593409.5; ENSP00000469962.1; ENSG00000214046.9.
DR Ensembl; ENST00000597781.5; ENSP00000469440.1; ENSG00000214046.9.
DR Ensembl; ENST00000599310.5; ENSP00000469918.1; ENSG00000214046.9.
DR GeneID; 79086; -.
DR KEGG; hsa:79086; -.
DR MANE-Select; ENST00000487416.7; ENSP00000417147.1; NM_024104.4; NP_077009.2.
DR UCSC; uc002ner.4; human.
DR CTD; 79086; -.
DR GeneCards; SMIM7; -.
DR HGNC; HGNC:28419; SMIM7.
DR HPA; ENSG00000214046; Low tissue specificity.
DR neXtProt; NX_Q9BQ49; -.
DR OpenTargets; ENSG00000214046; -.
DR PharmGKB; PA144596475; -.
DR VEuPathDB; HostDB:ENSG00000214046; -.
DR eggNOG; ENOG502S4E0; Eukaryota.
DR GeneTree; ENSGT00390000014626; -.
DR HOGENOM; CLU_181165_0_0_1; -.
DR InParanoid; Q9BQ49; -.
DR OMA; IAMWNIF; -.
DR PhylomeDB; Q9BQ49; -.
DR TreeFam; TF332999; -.
DR PathwayCommons; Q9BQ49; -.
DR SignaLink; Q9BQ49; -.
DR BioGRID-ORCS; 79086; 33 hits in 1062 CRISPR screens.
DR ChiTaRS; SMIM7; human.
DR GenomeRNAi; 79086; -.
DR Pharos; Q9BQ49; Tdark.
DR PRO; PR:Q9BQ49; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9BQ49; protein.
DR Bgee; ENSG00000214046; Expressed in islet of Langerhans and 206 other tissues.
DR ExpressionAtlas; Q9BQ49; baseline and differential.
DR Genevisible; Q9BQ49; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR037659; SMIM7.
DR PANTHER; PTHR28622; PTHR28622; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..75
FT /note="Small integral membrane protein 7"
FT /id="PRO_0000284047"
FT TOPO_DOM 18..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 75 AA; 8631 MW; 5CF77700933970D2 CRC64;
MIGDILLFGT LLMNAGAVLN FKLKKKDTQG FGEESREPST GDNIREFLLS LRYFRIFIAL
WNIFMMFCMI VLFGS
