ID   SMIM8_HUMAN             Reviewed;          97 AA.
AC   Q96KF7; B2R4V6; E1P505; Q5TEZ3; Q6NSD2; Q8IZ10;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Small integral membrane protein 8;
GN   Name=SMIM8; Synonyms=C6orf162; ORFNames=DC18;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Dendritic cell;
RA   Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.;
RT   "A novel gene from human dendritic cells.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hippocampus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SMIM8 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK38513.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF311339; AAK38513.1; ALT_FRAME; mRNA.
DR   EMBL; AK311963; BAG34903.1; -; mRNA.
DR   EMBL; AL096817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW48602.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW48603.1; -; Genomic_DNA.
DR   EMBL; BC070260; AAH70260.1; -; mRNA.
DR   CCDS; CCDS34496.1; -.
DR   RefSeq; NP_001035958.1; NM_001042493.2.
DR   RefSeq; NP_065158.3; NM_020425.5.
DR   AlphaFoldDB; Q96KF7; -.
DR   BioGRID; 121407; 22.
DR   IntAct; Q96KF7; 1.
DR   STRING; 9606.ENSP00000376603; -.
DR   iPTMnet; Q96KF7; -.
DR   PhosphoSitePlus; Q96KF7; -.
DR   BioMuta; SMIM8; -.
DR   DMDM; 71152382; -.
DR   EPD; Q96KF7; -.
DR   jPOST; Q96KF7; -.
DR   MassIVE; Q96KF7; -.
DR   MaxQB; Q96KF7; -.
DR   PaxDb; Q96KF7; -.
DR   PeptideAtlas; Q96KF7; -.
DR   PRIDE; Q96KF7; -.
DR   ProteomicsDB; 77066; -.
DR   TopDownProteomics; Q96KF7; -.
DR   Antibodypedia; 2342; 12 antibodies from 7 providers.
DR   DNASU; 57150; -.
DR   Ensembl; ENST00000229570.9; ENSP00000229570.5; ENSG00000111850.11.
DR   Ensembl; ENST00000392863.6; ENSP00000376603.1; ENSG00000111850.11.
DR   Ensembl; ENST00000608353.5; ENSP00000477133.1; ENSG00000111850.11.
DR   Ensembl; ENST00000608868.2; ENSP00000476945.1; ENSG00000111850.11.
DR   GeneID; 57150; -.
DR   KEGG; hsa:57150; -.
DR   MANE-Select; ENST00000392863.6; ENSP00000376603.1; NM_001042493.3; NP_001035958.1.
DR   UCSC; uc003plp.2; human.
DR   CTD; 57150; -.
DR   DisGeNET; 57150; -.
DR   GeneCards; SMIM8; -.
DR   HGNC; HGNC:21401; SMIM8.
DR   HPA; ENSG00000111850; Low tissue specificity.
DR   neXtProt; NX_Q96KF7; -.
DR   OpenTargets; ENSG00000111850; -.
DR   PharmGKB; PA134961667; -.
DR   VEuPathDB; HostDB:ENSG00000111850; -.
DR   eggNOG; ENOG502S4X3; Eukaryota.
DR   GeneTree; ENSGT00390000011674; -.
DR   HOGENOM; CLU_170028_0_0_1; -.
DR   InParanoid; Q96KF7; -.
DR   OMA; EGERYMR; -.
DR   OrthoDB; 1574927at2759; -.
DR   PhylomeDB; Q96KF7; -.
DR   TreeFam; TF323863; -.
DR   PathwayCommons; Q96KF7; -.
DR   SignaLink; Q96KF7; -.
DR   BioGRID-ORCS; 57150; 8 hits in 1025 CRISPR screens.
DR   GenomeRNAi; 57150; -.
DR   Pharos; Q96KF7; Tdark.
DR   PRO; PR:Q96KF7; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q96KF7; protein.
DR   Bgee; ENSG00000111850; Expressed in buccal mucosa cell and 181 other tissues.
DR   ExpressionAtlas; Q96KF7; baseline and differential.
DR   Genevisible; Q96KF7; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026686; UPF0708.
DR   PANTHER; PTHR14274; PTHR14274; 1.
DR   Pfam; PF14937; DUF4500; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..97
FT                   /note="Small integral membrane protein 8"
FT                   /id="PRO_0000089550"
FT   TRANSMEM        48..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   97 AA;  11059 MW;  50F00DE39A4C306F CRC64;
     MSSAPEPPTF KKEPPKEKEF QSPGLRGVRT TTLFRAVNPE LFIKPNKPVM AFGLVTLSLC
     VAYIGYLHAI QENKKDLYEA IDSEGHSYMR RKTSKWD