SMIM8_MOUSE
ID SMIM8_MOUSE Reviewed; 97 AA.
AC Q9CQQ0; Q9CY70;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Small integral membrane protein 8;
GN Name=Smim8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMIM8 family. {ECO:0000305}.
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DR EMBL; AK005941; BAB24328.1; -; mRNA.
DR EMBL; AK007303; BAB24944.1; -; mRNA.
DR EMBL; AK007660; BAB25170.1; -; mRNA.
DR EMBL; AK021236; BAB32341.1; -; mRNA.
DR EMBL; BC027508; AAH27508.1; -; mRNA.
DR CCDS; CCDS38706.1; -.
DR RefSeq; NP_001317684.1; NM_001330755.1.
DR RefSeq; NP_001317685.1; NM_001330756.1.
DR RefSeq; NP_001317686.1; NM_001330757.1.
DR RefSeq; NP_079747.1; NM_025471.3.
DR RefSeq; XP_006538226.1; XM_006538163.2.
DR AlphaFoldDB; Q9CQQ0; -.
DR STRING; 10090.ENSMUSP00000029972; -.
DR PhosphoSitePlus; Q9CQQ0; -.
DR EPD; Q9CQQ0; -.
DR MaxQB; Q9CQQ0; -.
DR PaxDb; Q9CQQ0; -.
DR PeptideAtlas; Q9CQQ0; -.
DR PRIDE; Q9CQQ0; -.
DR ProteomicsDB; 261438; -.
DR Antibodypedia; 2342; 12 antibodies from 7 providers.
DR DNASU; 66291; -.
DR Ensembl; ENSMUST00000029972; ENSMUSP00000029972; ENSMUSG00000028295.
DR Ensembl; ENSMUST00000108131; ENSMUSP00000103766; ENSMUSG00000028295.
DR Ensembl; ENSMUST00000108132; ENSMUSP00000103767; ENSMUSG00000028295.
DR Ensembl; ENSMUST00000108133; ENSMUSP00000103768; ENSMUSG00000028295.
DR Ensembl; ENSMUST00000108134; ENSMUSP00000103769; ENSMUSG00000028295.
DR GeneID; 66291; -.
DR KEGG; mmu:66291; -.
DR UCSC; uc008sgl.1; mouse.
DR CTD; 57150; -.
DR MGI; MGI:1913541; Smim8.
DR VEuPathDB; HostDB:ENSMUSG00000028295; -.
DR eggNOG; ENOG502S4X3; Eukaryota.
DR GeneTree; ENSGT00390000011674; -.
DR HOGENOM; CLU_170028_0_0_1; -.
DR InParanoid; Q9CQQ0; -.
DR OMA; EGERYMR; -.
DR OrthoDB; 1574927at2759; -.
DR PhylomeDB; Q9CQQ0; -.
DR TreeFam; TF323863; -.
DR BioGRID-ORCS; 66291; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Smim8; mouse.
DR PRO; PR:Q9CQQ0; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CQQ0; protein.
DR Bgee; ENSMUSG00000028295; Expressed in interventricular septum and 252 other tissues.
DR Genevisible; Q9CQQ0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026686; UPF0708.
DR PANTHER; PTHR14274; PTHR14274; 1.
DR Pfam; PF14937; DUF4500; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..97
FT /note="Small integral membrane protein 8"
FT /id="PRO_0000089551"
FT TRANSMEM 48..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 50
FT /note="M -> I (in Ref. 1; BAB32341)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 97 AA; 11064 MW; 6C9F58022D528DF9 CRC64;
MSSAPDPPTV KKEPLKEKNF ENPGLRGAHT TTLFRAVNPE LFIKPNKPVM AFGLVTLSLC
VAYIGYLHAT QENRKDLYEA IDSEGHRYMR RKTSKWD
