SMLA_DICDI
ID SMLA_DICDI Reviewed; 283 AA.
AC P54661; Q23850; Q54K48;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Small aggregate formation protein;
GN Name=smlA; ORFNames=DDB_G0287587;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8787732; DOI=10.1242/dev.122.9.2569;
RA Brock D.A., Buczynski G., Spann T.P., Wood S.A., Cardelli J., Gomer R.H.;
RT "A Dictystelium mutant with defective aggregate size determination.";
RL Development 122:2569-2578(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91.
RC STRAIN=AX3;
RX PubMed=2926809; DOI=10.1016/0022-2836(89)90364-1;
RA Giorda R., Ohmachi T., Ennis H.L.;
RT "Organization of a gene family developmentally regulated during
RT Dictyostelium discoideum spore germination.";
RL J. Mol. Biol. 205:63-69(1989).
CC -!- FUNCTION: Knockout of the gene for this protein causes small aggregate
CC formation. May regulate the secretion or processing of a secreted
CC factor that regulates aggregate size.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- DEVELOPMENTAL STAGE: Expressed in vegetative and early developing
CC cells, its level decreases at about 10 hours of development.
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DR EMBL; U48706; AAB19231.1; -; Genomic_DNA.
DR EMBL; AAFI02000103; EAL63602.1; -; Genomic_DNA.
DR EMBL; M19469; AAA67428.1; -; Genomic_DNA.
DR RefSeq; XP_637116.1; XM_632024.1.
DR AlphaFoldDB; P54661; -.
DR SMR; P54661; -.
DR STRING; 44689.DDB0191525; -.
DR TCDB; 1.C.59.4.1; the clostridium perfringens enterotoxin (cpe) family.
DR PaxDb; P54661; -.
DR EnsemblProtists; EAL63602; EAL63602; DDB_G0287587.
DR GeneID; 8626211; -.
DR KEGG; ddi:DDB_G0287587; -.
DR dictyBase; DDB_G0287587; smlA.
DR HOGENOM; CLU_085553_0_0_1; -.
DR InParanoid; P54661; -.
DR PhylomeDB; P54661; -.
DR PRO; PR:P54661; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:dictyBase.
DR GO; GO:0042593; P:glucose homeostasis; IMP:dictyBase.
DR GO; GO:0031159; P:positive regulation of aggregate size involved in sorocarp development; IGI:dictyBase.
DR GO; GO:0032114; P:regulation of glucose-6-phosphatase activity; IMP:dictyBase.
DR GO; GO:0050708; P:regulation of protein secretion; IMP:dictyBase.
DR GO; GO:0007165; P:signal transduction; IMP:dictyBase.
DR InterPro; IPR040927; BB_PF.
DR InterPro; IPR038768; SmlA.
DR PANTHER; PTHR35884; PTHR35884; 1.
DR Pfam; PF18063; BB_PF; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..283
FT /note="Small aggregate formation protein"
FT /id="PRO_0000071975"
FT CONFLICT 9
FT /note="E -> V (in Ref. 1; AAB19231)"
FT /evidence="ECO:0000305"
FT CONFLICT 34
FT /note="Q -> P (in Ref. 1; AAB19231)"
FT /evidence="ECO:0000305"
FT CONFLICT 52..66
FT /note="QNFDFENAKIVSTNF -> PNLGFGKMLKLFQPIW (in Ref. 1;
FT AAB19231)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 283 AA; 33173 MW; 7C3CC6E27660A36A CRC64;
MEEIKETVEK KNKEKKYLND YKIISEGNNI KVLQKKDFKP KFSLVSYKNY EQNFDFENAK
IVSTNFAIDR HIKMKNPPDP FVFIKMPSSK LVQSQLKLYY ENEGYKDIPV WITPCSAFMR
YIKSYPIVGT VTETMEKKKG FTNRFLSTSE TKASVSVGFF GCESSMEVTS GYEYEDTVTS
EETRSWSQTL NEGSYIVYQN VLVYAYIIYG GSYKPYIDQM NKFNPGLNIK FFREDKCIFF
VPINRDDAFT LRYQDNTWDP VEYDVLIDYL GQNQDKWFSG GLP
