SMLR1_HUMAN
ID SMLR1_HUMAN Reviewed; 107 AA.
AC H3BR10;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Small leucine-rich protein 1;
GN Name=SMLR1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC H3BR10; Q96G97-4: BSCL2; NbExp=3; IntAct=EBI-10178109, EBI-10178113;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL109938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113027; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59036.1; -.
DR RefSeq; NP_001182526.1; NM_001195597.1.
DR AlphaFoldDB; H3BR10; -.
DR BioGRID; 130191; 2.
DR IntAct; H3BR10; 1.
DR STRING; 9606.ENSP00000456026; -.
DR iPTMnet; H3BR10; -.
DR PhosphoSitePlus; H3BR10; -.
DR BioMuta; SMLR1; -.
DR MassIVE; H3BR10; -.
DR PaxDb; H3BR10; -.
DR PeptideAtlas; H3BR10; -.
DR PRIDE; H3BR10; -.
DR Antibodypedia; 74935; 4 antibodies from 4 providers.
DR DNASU; 100507203; -.
DR Ensembl; ENST00000541421.2; ENSP00000456026.1; ENSG00000256162.2.
DR GeneID; 100507203; -.
DR KEGG; hsa:100507203; -.
DR MANE-Select; ENST00000541421.2; ENSP00000456026.1; NM_001195597.2; NP_001182526.1.
DR UCSC; uc011ebx.3; human.
DR CTD; 100507203; -.
DR DisGeNET; 100507203; -.
DR GeneCards; SMLR1; -.
DR HGNC; HGNC:44670; SMLR1.
DR HPA; ENSG00000256162; Tissue enriched (liver).
DR neXtProt; NX_H3BR10; -.
DR OpenTargets; ENSG00000256162; -.
DR VEuPathDB; HostDB:ENSG00000256162; -.
DR eggNOG; ENOG502SYE8; Eukaryota.
DR GeneTree; ENSGT00560000078592; -.
DR HOGENOM; CLU_176395_0_0_1; -.
DR InParanoid; H3BR10; -.
DR OMA; QTCDRQY; -.
DR OrthoDB; 1633725at2759; -.
DR PathwayCommons; H3BR10; -.
DR BioGRID-ORCS; 100507203; 7 hits in 1053 CRISPR screens.
DR GenomeRNAi; 100507203; -.
DR Pharos; H3BR10; Tdark.
DR PRO; PR:H3BR10; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; H3BR10; protein.
DR Bgee; ENSG00000256162; Expressed in jejunal mucosa and 39 other tissues.
DR Genevisible; H3BR10; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..107
FT /note="Small leucine-rich protein 1"
FT /id="PRO_0000421260"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 85..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 107 AA; 12312 MW; 9AA9B68B58A3B01F CRC64;
MLSKGRSPRR KQVQTQRKAA LVLSVTPMVP VGSVWLAMSS VLSAFMRELP GWFLFFGVFL
PVTLLLLLLI AYFRIKLIEV NEELSQNCDR QHNPKDGSSL YQRMKWT
