SMN1_DICDI
ID SMN1_DICDI Reviewed; 370 AA.
AC Q86AD2; Q551R9;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Component of gems protein 1;
DE AltName: Full=Gemin-1;
GN Name=gemin1; ORFNames=DDB_G0276357;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May play an essential role in spliceosomal snRNP assembly in
CC the cytoplasm and may be required for pre-mRNA splicing in the nucleus.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, gem {ECO:0000305}. Cytoplasm
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMN family. {ECO:0000305}.
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DR EMBL; AAFI02000014; EAL69259.1; -; Genomic_DNA.
DR RefSeq; XP_643192.1; XM_638100.1.
DR AlphaFoldDB; Q86AD2; -.
DR SMR; Q86AD2; -.
DR STRING; 44689.DDB0302537; -.
DR PaxDb; Q86AD2; -.
DR PRIDE; Q86AD2; -.
DR EnsemblProtists; EAL69259; EAL69259; DDB_G0276357.
DR GeneID; 8620465; -.
DR KEGG; ddi:DDB_G0276357; -.
DR dictyBase; DDB_G0276357; gemin1.
DR eggNOG; ENOG502RI1P; Eukaryota.
DR HOGENOM; CLU_748917_0_0_1; -.
DR InParanoid; Q86AD2; -.
DR OMA; ENENDMR; -.
DR PRO; PR:Q86AD2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0097504; C:Gemini of coiled bodies; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR010304; SMN_Tudor.
DR Pfam; PF06003; SMN; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; RNA-binding; Spliceosome.
FT CHAIN 1..370
FT /note="Component of gems protein 1"
FT /id="PRO_0000371340"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 39..135
FT /evidence="ECO:0000255"
FT COMPBIAS 7..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 44154 MW; FC0056BC6774F3F9 CRC64;
MKKKITETSS IMFSSPKNQQ SKQYINENVW DDQYLIDVYE KSINQYIEAH NEKNKKNRNK
NKEINNVEDD ISNNNNNNNS NNKTIDNNKN KIGSKNNINN NSTTTNTNKN KINKQKQQQQ
NNLDKETDTK DDYNSGDYYN EYEDDNGEDN DYQERKGYYQ SNKDHDYYHN GENNYQNQYN
PNYFYQSQHY QQQQPPQNFN NQYQPHHHHH HHQQYPNHHS YNYNREQYQN PYSQPPPTPT
NYPPMQTNFQ PPPMPTILPQ GDDELADLLL SWYYSGYYTG VYQERKRNSR LNQTPHPNHI
NHHRYNNNNN NNNNNNNNNN NNNNNNNNNN NNSNNNNNNN NNNNNNKSNS NSNNKKLPKF
TNIPKTKETN
