ID   SMOX2_SCHMA             Reviewed;         524 AA.
AC   Q26601;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Homeobox protein engrailed-like SMOX-2;
GN   Name=SMOX-2;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Puerto Rican;
RX   PubMed=1356008; DOI=10.1016/0925-4773(92)90035-i;
RA   Webster P.J., Mansour T.E.;
RT   "Conserved classes of homeodomains in Schistosoma mansoni, an early
RT   bilateral metazoan.";
RL   Mech. Dev. 38:25-32(1992).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR   EMBL; M85305; AAA29929.1; -; mRNA.
DR   PIR; S33640; S33640.
DR   AlphaFoldDB; Q26601; -.
DR   SMR; Q26601; -.
DR   STRING; 6183.Smp_145200.1; -.
DR   eggNOG; KOG0493; Eukaryota.
DR   HOGENOM; CLU_051739_0_0_1; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000747; Homeobox_engrailed.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR019737; Homoebox-engrailed_CS.
DR   Pfam; PF10525; Engrail_1_C_sig; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00026; ENGRAILED.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00033; ENGRAILED; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..524
FT                   /note="Homeobox protein engrailed-like SMOX-2"
FT                   /id="PRO_0000196089"
FT   DNA_BIND        423..482
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          194..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   524 AA;  60368 MW;  63972F17DE0EC626 CRC64;
     MFKLLDNFNE KSKSIMIEQM KQQYCLLQYD KEMVTNFLNF INHHYIWNCY HNNSNNSYNN
     DLDMNNIQEK LIIEHLDPLM LINSYTDYPF WSSMLMLAVN EAVTTTTTTT TTTTTSTTTT
     TSGIIPLSST IIPSTIISPV KTSLSSLSMM TIDDLQNDIS KINYEEDFFS KLLKCTLIRN
     ENSYSNEIEQ LSLSSSSSSS SSSSSSSSSS SCSTNSSSSV YMSEKKANGF FVKDILSFDK
     HKVIRRQKTD DSFEKEVLVK GRDEEKKEEV QGRQKKDNIN KYKIINCTDI SHNNMNYVCD
     NSKEPQVENL QKNKLINKFT VGSEEEEDND DINDAAKNNN TNYLRKTVSD DGMKLKSNRN
     HNKKLGSRGR IHEITSSNKL NTNDPSRLHL PAWVFCTRYS DRPSSGPRIR KPRMNRSNDE
     LNLKRPRTSF TVPQLKRLSQ EFEKNRYLDE LRRKKLATEL DLRESQVKIW FQNKRAKTKK
     ASGAQNCLAL HLMAEGLYNH SVRVRSDIEE DEEDSDDMNT SEKE