SMO_CHICK
ID SMO_CHICK Reviewed; 794 AA.
AC O42224;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Smoothened homolog;
DE Short=SMO;
DE Flags: Precursor; Fragment;
GN Name=SMO; Synonyms=SMOH;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9598354;
RA Quirk J., van den Heuvel M., Henrique D., Marigo V., Sheer D., Tabin C.,
RA Ingham P.W.;
RT "The smoothened gene and hedgehog signal transduction in Drosophila and
RT vertebrate development.";
RL Cold Spring Harb. Symp. Quant. Biol. 62:217-226(1997).
CC -!- FUNCTION: G protein-coupled receptor that probably associates with the
CC patched protein (PTCH) to transduce the hedgehog's proteins signal.
CC Binding of sonic hedgehog (SHH) to its receptor patched is thought to
CC prevent normal inhibition by patched of smoothened (SMO).
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000305}.
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DR EMBL; AF019977; AAB84389.1; -; mRNA.
DR AlphaFoldDB; O42224; -.
DR SMR; O42224; -.
DR STRING; 9031.ENSGALP00000039562; -.
DR VEuPathDB; HostDB:geneid_395949; -.
DR eggNOG; KOG3577; Eukaryota.
DR InParanoid; O42224; -.
DR PhylomeDB; O42224; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005113; F:patched binding; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0071679; P:commissural neuron axon guidance; IBA:GO_Central.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IBA:GO_Central.
DR CDD; cd15030; 7tmF_SMO_homolog; 1.
DR CDD; cd07451; CRD_SMO; 1.
DR Gene3D; 1.10.2000.10; -; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR026544; SMO.
DR InterPro; IPR035683; SMO_7TM.
DR InterPro; IPR041771; SMO_CRD.
DR PANTHER; PTHR11309; PTHR11309; 1.
DR PANTHER; PTHR11309:SF35; PTHR11309:SF35; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; SSF63501; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transducer;
KW Transmembrane; Transmembrane helix.
FT SIGNAL <1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..794
FT /note="Smoothened homolog"
FT /id="PRO_0000013018"
FT TOPO_DOM 16..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 253..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 349..371
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 393..420
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..440
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 441..493
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..514
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 515..794
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 35..151
FT /note="FZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT REGION 634..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 278
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 462
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 40..104
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 48..97
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 88..124
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 117..139
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 163..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 187..264
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 283..359
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DISULFID 459..476
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT NON_TER 1
SQ SEQUENCE 794 AA; 88255 MW; CE71AE9864A6C0CB CRC64;
GPCWLWALAL GLALGPRRCP AAPLNASAAP PERCRRPAAC ERLRFGSCLG SALPYAHTST
LLAADSGSQE EAHGKLLLWS GLRNAPRCWD VIQPLLCAVY MPKCEDGQVE LPSQTLCQAT
RAPCTIVERE RGWPDFLKCT PDRFPEGCPN EVQNIKFNSS GQCEAPLVRT YNPKSWYEDV
EGCGIQCQNP LFTETEHREM HVYIAFSSVT ISCTFFTLAT FVADWRNSNR YPAVILFYVN
ACFFVGSIGC VAQFMDGARD EIVCRADGTM RLGEPTSNET LSCVIIFVIV YYSLMSGVIW
FVMLTYAWHT SFKALGTTYQ PLLGKTSYFH LITWSIPFVL TVAILAVAQV DGDSVSGICF
VGYKNYRYRA GFVLAPIGLV LIVGGYFLIR GVMTLFSIKS NHPGLLSEKA ASKINETMLR
LGIFGFLAFG FVFITFGCHF YDFFNQAEWE RSFREYVLCE ANVTIATQTN KPIPECEIKN
RPSLLVEKIN LFAMFGTGIS MSTWVWTKAT LLIWKRTWCR LTGQSDDQPK RIKKSKMIAK
AFSKRKELLR DPGRELSFSM HTVSHDGPVA GLAFDINEPS ADVSSAWAQH VTKMVARRGA
ILPQDVSVTP VATPVPPEER SNLWVVEADV SPELQKRSRK KKRRKKKKEE VCPERRAGLS
VAPLTPSSVP RLPRLPQQPC LVAIPRHRGD TFIPTVLPGL SNGAGGLWDG RRRAHVPHFI
TNPFCPESGS PEDEENPGPS VGHRQHNGGR RWPPEPLPGG SGVTRTRGRR AGLAPIHSRT
NLVNAELLDA DLDF
