SMPX_MOUSE
ID SMPX_MOUSE Reviewed; 85 AA.
AC Q9DC77; A2RT38; Q4QRM9; Q8CEX8; Q9ER98;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Small muscular protein;
DE AltName: Full=Stretch-responsive skeletal muscle protein;
DE Short=Chisel protein;
GN Name=Smpx; Synonyms=Csl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10598820; DOI=10.1007/s004390051138;
RA Patzak D., Zhuchenko O., Lee C.-C., Wehnert M.;
RT "Identification, mapping, and genomic structure of a novel X-chromosomal
RT human gene (SMPX) encoding a small muscular protein.";
RL Hum. Genet. 105:506-512(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/10; TISSUE=Skeletal muscle;
RX PubMed=11401441; DOI=10.1006/geno.2000.6461;
RA Kemp T.J., Sadusky T.J., Simon M., Brown R., Eastwood M., Sassoon D.A.,
RA Coulton G.R.;
RT "Identification of a novel stretch-responsive skeletal muscle gene
RT (Smpx).";
RL Genomics 72:260-271(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=C57BL/6J;
RX PubMed=11381084; DOI=10.1083/jcb.153.5.985;
RA Palmer S., Groves N., Schindeler A., Yeoh T., Biben C., Wang C.-C.,
RA Sparrow D.B., Barnett L., Jenkins N.A., Copeland N.G., Koentgen F.,
RA Mohun T., Harvey R.P.;
RT "The small muscle-specific protein Csl modifies cell shape and promotes
RT myocyte fusion in an insulin-like growth factor 1-dependent manner.";
RL J. Cell Biol. 153:985-998(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart, Lung, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in the regulatory network through which muscle
CC cells coordinate their structural and functional states during growth,
CC adaptation, and repair. {ECO:0000269|PubMed:11381084}.
CC -!- TISSUE SPECIFICITY: Abundantly expressed in heart and skeletal muscle.
CC Expression is increased by passive stretch.
CC {ECO:0000269|PubMed:10598820, ECO:0000269|PubMed:11401441}.
CC -!- SIMILARITY: Belongs to the SMPX family. {ECO:0000305}.
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DR EMBL; AF364070; AAK50398.1; -; mRNA.
DR EMBL; AJ245772; CAC08493.1; -; mRNA.
DR EMBL; AY026524; AAK07682.1; -; mRNA.
DR EMBL; AK003105; BAB22568.2; -; mRNA.
DR EMBL; AK009857; BAC25273.1; -; mRNA.
DR EMBL; AK010172; BAC25284.1; -; mRNA.
DR EMBL; AL731811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466571; EDL40828.1; -; Genomic_DNA.
DR EMBL; CH466571; EDL40829.1; -; Genomic_DNA.
DR EMBL; CH466571; EDL40831.1; -; Genomic_DNA.
DR EMBL; BC051197; AAH51197.1; -; mRNA.
DR EMBL; BC061051; AAH61051.1; -; mRNA.
DR EMBL; BC132358; AAI32359.1; -; mRNA.
DR EMBL; BC138801; AAI38802.1; -; mRNA.
DR CCDS; CCDS41190.1; -.
DR RefSeq; NP_001239520.1; NM_001252591.2.
DR AlphaFoldDB; Q9DC77; -.
DR BioGRID; 211217; 1.
DR STRING; 10090.ENSMUSP00000108140; -.
DR iPTMnet; Q9DC77; -.
DR PhosphoSitePlus; Q9DC77; -.
DR MaxQB; Q9DC77; -.
DR PaxDb; Q9DC77; -.
DR PeptideAtlas; Q9DC77; -.
DR PRIDE; Q9DC77; -.
DR ProteomicsDB; 257273; -.
DR Antibodypedia; 24455; 93 antibodies from 22 providers.
DR DNASU; 66106; -.
DR Ensembl; ENSMUST00000038007; ENSMUSP00000048522; ENSMUSG00000041476.
DR Ensembl; ENSMUST00000112520; ENSMUSP00000108139; ENSMUSG00000041476.
DR Ensembl; ENSMUST00000112521; ENSMUSP00000108140; ENSMUSG00000041476.
DR Ensembl; ENSMUST00000190091; ENSMUSP00000140268; ENSMUSG00000041476.
DR GeneID; 66106; -.
DR KEGG; mmu:66106; -.
DR UCSC; uc009use.2; mouse.
DR CTD; 23676; -.
DR MGI; MGI:1913356; Smpx.
DR VEuPathDB; HostDB:ENSMUSG00000041476; -.
DR eggNOG; ENOG502S62J; Eukaryota.
DR GeneTree; ENSGT00390000017542; -.
DR HOGENOM; CLU_2512070_0_0_1; -.
DR InParanoid; Q9DC77; -.
DR OMA; PPRKKEC; -.
DR OrthoDB; 1588044at2759; -.
DR PhylomeDB; Q9DC77; -.
DR TreeFam; TF338181; -.
DR BioGRID-ORCS; 66106; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9DC77; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9DC77; protein.
DR Bgee; ENSMUSG00000041476; Expressed in atrioventricular valve and 151 other tissues.
DR ExpressionAtlas; Q9DC77; baseline and differential.
DR Genevisible; Q9DC77; MM.
DR GO; GO:0043292; C:contractile fiber; IDA:MGI.
DR GO; GO:0043034; C:costamere; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0031430; C:M band; IDA:MGI.
DR GO; GO:0005927; C:muscle tendon junction; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR InterPro; IPR029268; Chisel.
DR PANTHER; PTHR17416; PTHR17416; 1.
DR Pfam; PF15355; Chisel; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..85
FT /note="Small muscular protein"
FT /id="PRO_0000071979"
FT REGION 19..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q925F0"
FT MOD_RES 47
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q925F0"
FT CONFLICT 53..54
FT /note="Missing (in Ref. 4; BAC25273)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 85 AA; 9253 MW; 43863840A65DA6BC CRC64;
MSKQPISNVR AIQANINIPM GAFRPGAGQP PRRKESTPET EEGAPTTSEE KKPIPGMKKF
PGPVVNLSEI QNVKSELKFV PKGEQ
