SMR11_ARATH
ID SMR11_ARATH Reviewed; 154 AA.
AC Q9SKN7; Q8LAW0;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Cyclin-dependent protein kinase inhibitor SMR11 {ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
DE AltName: Full=Protein SIAMESE-RELATED 11 {ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
GN Name=SMR11 {ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
GN OrderedLocusNames=At2g28330 {ECO:0000312|Araport:AT2G28330};
GN ORFNames=T1B3.15 {ECO:0000312|EMBL:AAD20692.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INTERACTION WITH CYCB2-4.
RX PubMed=20706207; DOI=10.1038/msb.2010.53;
RA Van Leene J., Hollunder J., Eeckhout D., Persiau G., Van De Slijke E.,
RA Stals H., Van Isterdael G., Verkest A., Neirynck S., Buffel Y., De Bodt S.,
RA Maere S., Laukens K., Pharazyn A., Ferreira P.C.G., Eloy N., Renne C.,
RA Meyer C., Faure J.-D., Steinbrenner J., Beynon J., Larkin J.C.,
RA Van de Peer Y., Hilson P., Kuiper M., De Veylder L., Van Onckelen H.,
RA Inze D., Witters E., De Jaeger G.;
RT "Targeted interactomics reveals a complex core cell cycle machinery in
RT Arabidopsis thaliana.";
RL Mol. Syst. Biol. 6:397-397(2010).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24399300; DOI=10.1105/tpc.113.118943;
RA Yi D., Alvim Kamei C.L., Cools T., Vanderauwera S., Takahashi N.,
RA Okushima Y., Eekhout T., Yoshiyama K.O., Larkin J., Van den Daele H.,
RA Conklin P., Britt A., Umeda M., De Veylder L.;
RT "The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5
RT and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen
RT species.";
RL Plant Cell 26:296-309(2014).
RN [7]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=26546445; DOI=10.1105/tpc.15.00489;
RA Kumar N., Harashima H., Kalve S., Bramsiepe J., Wang K., Sizani B.L.,
RA Bertrand L.L., Johnson M.C., Faulk C., Dale R., Simmons L.A.,
RA Churchman M.L., Sugimoto K., Kato N., Dasanayake M., Beemster G.,
RA Schnittger A., Larkin J.C.;
RT "Functional conservation in the SIAMESE-RELATED family of cyclin-dependent
RT kinase inhibitors in land plants.";
RL Plant Cell 27:3065-3080(2015).
CC -!- FUNCTION: Probable cyclin-dependent protein kinase (CDK) inhibitor that
CC functions as a repressor of mitosis in the endoreduplication cell
CC cycle. {ECO:0000269|PubMed:26546445}.
CC -!- SUBUNIT: Interacts with CYCB2-4 (PubMed:20706207).
CC {ECO:0000269|PubMed:20706207}.
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DR EMBL; AC006283; AAD20692.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08108.1; -; Genomic_DNA.
DR EMBL; BT024761; ABD59099.1; -; mRNA.
DR EMBL; AY087573; AAM65115.1; -; mRNA.
DR PIR; E84683; E84683.
DR RefSeq; NP_565669.1; NM_128392.4.
DR AlphaFoldDB; Q9SKN7; -.
DR IntAct; Q9SKN7; 1.
DR STRING; 3702.AT2G28330.1; -.
DR iPTMnet; Q9SKN7; -.
DR PaxDb; Q9SKN7; -.
DR PRIDE; Q9SKN7; -.
DR ProteomicsDB; 228447; -.
DR EnsemblPlants; AT2G28330.1; AT2G28330.1; AT2G28330.
DR GeneID; 817380; -.
DR Gramene; AT2G28330.1; AT2G28330.1; AT2G28330.
DR KEGG; ath:AT2G28330; -.
DR Araport; AT2G28330; -.
DR TAIR; locus:2057537; AT2G28330.
DR eggNOG; ENOG502R7KQ; Eukaryota.
DR HOGENOM; CLU_163607_0_0_1; -.
DR InParanoid; Q9SKN7; -.
DR OMA; GSAETWC; -.
DR OrthoDB; 1592392at2759; -.
DR PhylomeDB; Q9SKN7; -.
DR PRO; PR:Q9SKN7; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SKN7; baseline and differential.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR038971; SMR11/SMR16.
DR PANTHER; PTHR36310; PTHR36310; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Protein kinase inhibitor; Reference proteome.
FT CHAIN 1..154
FT /note="Cyclin-dependent protein kinase inhibitor SMR11"
FT /id="PRO_0000438470"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 28
FT /note="D -> G (in Ref. 4; AAM65115)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 154 AA; 16893 MW; 4ECA32D4632A2A30 CRC64;
MEQEEPCEAK ETASSSIEPK TPNPNVPDSI PAIDSDSSLS EEEIVTEKDR GIVTLSPLCK
QRIDSASISD CVLVSDDEII ESLYQNLLRV ILSLQQIQSV AVVPEIWCFD GCKTPPPSSR
NLDSNMVSDT CPGAPMKLTK ISRNIDSGLR RKLF
