SMR12_ARATH
ID SMR12_ARATH Reviewed; 161 AA.
AC O80930; A0MES4; Q1PEW1;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Cyclin-dependent protein kinase inhibitor SMR12 {ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
DE AltName: Full=Protein SIAMESE-RELATED 12 {ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
GN Name=SMR12 {ECO:0000303|PubMed:24399300, ECO:0000303|PubMed:26546445};
GN OrderedLocusNames=At2g37610 {ECO:0000312|Araport:AT2G37610};
GN ORFNames=F13M22.11 {ECO:0000312|EMBL:AAC23631.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 41-161.
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24399300; DOI=10.1105/tpc.113.118943;
RA Yi D., Alvim Kamei C.L., Cools T., Vanderauwera S., Takahashi N.,
RA Okushima Y., Eekhout T., Yoshiyama K.O., Larkin J., Van den Daele H.,
RA Conklin P., Britt A., Umeda M., De Veylder L.;
RT "The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5
RT and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen
RT species.";
RL Plant Cell 26:296-309(2014).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=26546445; DOI=10.1105/tpc.15.00489;
RA Kumar N., Harashima H., Kalve S., Bramsiepe J., Wang K., Sizani B.L.,
RA Bertrand L.L., Johnson M.C., Faulk C., Dale R., Simmons L.A.,
RA Churchman M.L., Sugimoto K., Kato N., Dasanayake M., Beemster G.,
RA Schnittger A., Larkin J.C.;
RT "Functional conservation in the SIAMESE-RELATED family of cyclin-dependent
RT kinase inhibitors in land plants.";
RL Plant Cell 27:3065-3080(2015).
CC -!- FUNCTION: Probable cyclin-dependent protein kinase (CDK) inhibitor that
CC functions as a repressor of mitosis in the endoreduplication cell
CC cycle. {ECO:0000250|UniProtKB:Q9LZ78}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28208.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC004684; AAC23631.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09425.1; -; Genomic_DNA.
DR EMBL; DQ446606; ABE65471.1; -; Genomic_DNA.
DR EMBL; DQ653046; ABK28208.1; ALT_SEQ; Genomic_DNA.
DR PIR; T02527; T02527.
DR RefSeq; NP_181297.1; NM_129317.2.
DR AlphaFoldDB; O80930; -.
DR STRING; 3702.AT2G37610.1; -.
DR PaxDb; O80930; -.
DR PRIDE; O80930; -.
DR EnsemblPlants; AT2G37610.1; AT2G37610.1; AT2G37610.
DR GeneID; 818338; -.
DR Gramene; AT2G37610.1; AT2G37610.1; AT2G37610.
DR KEGG; ath:AT2G37610; -.
DR Araport; AT2G37610; -.
DR TAIR; locus:2040766; AT2G37610.
DR eggNOG; ENOG502R1Q4; Eukaryota.
DR HOGENOM; CLU_139385_0_0_1; -.
DR InParanoid; O80930; -.
DR OMA; ENRIPEM; -.
DR OrthoDB; 1493511at2759; -.
DR PhylomeDB; O80930; -.
DR PRO; PR:O80930; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80930; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0045839; P:negative regulation of mitotic nuclear division; IBA:GO_Central.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IEA:InterPro.
DR InterPro; IPR040389; SMR.
DR PANTHER; PTHR33142; PTHR33142; 1.
PE 3: Inferred from homology;
KW Cell cycle; Protein kinase inhibitor; Reference proteome.
FT CHAIN 1..161
FT /note="Cyclin-dependent protein kinase inhibitor SMR12"
FT /id="PRO_0000438471"
FT REGION 84..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 161 AA; 19129 MW; 5DBA3170A33ACB24 CRC64;
MEIGNVKADV NLVLNLREAE RHRRYFDYFI DEILWLSFLG MSETSLKEEE VTLGGVKETR
EEECSDDKLV LDICLKRKRL DEEEEEEVVE EENDGFKTPT RPENRIPIVR ECPPAPMKRS
SEMFRGRTMY CRRRLSFLPE DDVNSFITDL QWRTTTMTIK K
