SMR14_ARATH
ID SMR14_ARATH Reviewed; 154 AA.
AC Q9LTJ2;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Cyclin-dependent protein kinase inhibitor SMR14 {ECO:0000303|PubMed:26546445};
DE AltName: Full=Cyclin-dependent protein kinase inhibitor SMR13 {ECO:0000303|PubMed:24399300};
DE AltName: Full=Protein SIAMESE-RELATED 13 {ECO:0000303|PubMed:24399300};
DE AltName: Full=Protein SIAMESE-RELATED 14 {ECO:0000303|PubMed:26546445};
GN Name=SMR14 {ECO:0000303|PubMed:26546445};
GN Synonyms=SMR13 {ECO:0000303|PubMed:24399300};
GN OrderedLocusNames=At5g59360 {ECO:0000312|Araport:AT5G59360};
GN ORFNames=F2O15.2 {ECO:0000312|EMBL:BAA97472.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAA97472.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA / MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24399300; DOI=10.1105/tpc.113.118943;
RA Yi D., Alvim Kamei C.L., Cools T., Vanderauwera S., Takahashi N.,
RA Okushima Y., Eekhout T., Yoshiyama K.O., Larkin J., Van den Daele H.,
RA Conklin P., Britt A., Umeda M., De Veylder L.;
RT "The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5
RT and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen
RT species.";
RL Plant Cell 26:296-309(2014).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=26546445; DOI=10.1105/tpc.15.00489;
RA Kumar N., Harashima H., Kalve S., Bramsiepe J., Wang K., Sizani B.L.,
RA Bertrand L.L., Johnson M.C., Faulk C., Dale R., Simmons L.A.,
RA Churchman M.L., Sugimoto K., Kato N., Dasanayake M., Beemster G.,
RA Schnittger A., Larkin J.C.;
RT "Functional conservation in the SIAMESE-RELATED family of cyclin-dependent
RT kinase inhibitors in land plants.";
RL Plant Cell 27:3065-3080(2015).
CC -!- FUNCTION: Probable cyclin-dependent protein kinase (CDK) inhibitor that
CC functions as a repressor of mitosis in the endoreduplication cell
CC cycle. {ECO:0000250|UniProtKB:Q9LZ78}.
CC -!- CAUTION: This gene was called SMR13 in PubMed:24399300. {ECO:0000305}.
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DR EMBL; AB025604; BAA97472.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97175.1; -; Genomic_DNA.
DR EMBL; AY954877; AAX55203.1; -; Genomic_DNA.
DR EMBL; DQ132758; AAZ52788.1; -; mRNA.
DR RefSeq; NP_200744.1; NM_125327.3.
DR AlphaFoldDB; Q9LTJ2; -.
DR PaxDb; Q9LTJ2; -.
DR PRIDE; Q9LTJ2; -.
DR EnsemblPlants; AT5G59360.1; AT5G59360.1; AT5G59360.
DR GeneID; 836055; -.
DR Gramene; AT5G59360.1; AT5G59360.1; AT5G59360.
DR KEGG; ath:AT5G59360; -.
DR Araport; AT5G59360; -.
DR TAIR; locus:2148288; AT5G59360.
DR eggNOG; ENOG502SY5E; Eukaryota.
DR HOGENOM; CLU_1715743_0_0_1; -.
DR InParanoid; Q9LTJ2; -.
DR OMA; KRKWECE; -.
DR OrthoDB; 1599077at2759; -.
DR PRO; PR:Q9LTJ2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LTJ2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0045839; P:negative regulation of mitotic nuclear division; IBA:GO_Central.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IEA:InterPro.
DR InterPro; IPR040389; SMR.
DR PANTHER; PTHR33142; PTHR33142; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Protein kinase inhibitor; Reference proteome.
FT CHAIN 1..154
FT /note="Cyclin-dependent protein kinase inhibitor SMR14"
FT /id="PRO_0000438473"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 154 AA; 18003 MW; 8BA660E4F5A6D598 CRC64;
MSKIKIFHLF PDDKDIEATQ QPESLLVPSK SDSLDSSLSR HHQENQSNRQ RNHQHRQQDQ
ELENLQDGSR GKRKWECKDE ESPVKIPETP RNSNSVCYCP PRPPRKPKAI PSMKRRGMWV
KRSVVFLDVA REVESMFPPS VLQDFGKKIK KARF
