SMR15_ARATH
ID SMR15_ARATH Reviewed; 106 AA.
AC Q1G3Y4; A0MDJ5;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Cyclin-dependent protein kinase inhibitor SMR15 {ECO:0000303|PubMed:26546445};
DE AltName: Full=Protein SIAMESE-RELATED 15 {ECO:0000303|PubMed:26546445};
GN Name=SMR15 {ECO:0000303|PubMed:26546445};
GN OrderedLocusNames=At1g60783 {ECO:0000312|Araport:AT1G60783};
GN ORFNames=F8A5 {ECO:0000312|EMBL:AC002292};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:ABF59303.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=26546445; DOI=10.1105/tpc.15.00489;
RA Kumar N., Harashima H., Kalve S., Bramsiepe J., Wang K., Sizani B.L.,
RA Bertrand L.L., Johnson M.C., Faulk C., Dale R., Simmons L.A.,
RA Churchman M.L., Sugimoto K., Kato N., Dasanayake M., Beemster G.,
RA Schnittger A., Larkin J.C.;
RT "Functional conservation in the SIAMESE-RELATED family of cyclin-dependent
RT kinase inhibitors in land plants.";
RL Plant Cell 27:3065-3080(2015).
CC -!- FUNCTION: Probable cyclin-dependent protein kinase (CDK) inhibitor that
CC functions as a repressor of mitosis in the endoreduplication cell
CC cycle. {ECO:0000250|UniProtKB:Q9LZ78}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK27997.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC002292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE33732.1; -; Genomic_DNA.
DR EMBL; DQ487450; ABF59303.1; -; Genomic_DNA.
DR EMBL; DQ652611; ABK27997.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_001117521.1; NM_001124049.1.
DR AlphaFoldDB; Q1G3Y4; -.
DR PaxDb; Q1G3Y4; -.
DR PRIDE; Q1G3Y4; -.
DR EnsemblPlants; AT1G60783.1; AT1G60783.1; AT1G60783.
DR GeneID; 6240271; -.
DR Gramene; AT1G60783.1; AT1G60783.1; AT1G60783.
DR KEGG; ath:AT1G60783; -.
DR Araport; AT1G60783; -.
DR TAIR; locus:4515102692; AT1G60783.
DR HOGENOM; CLU_2226943_0_0_1; -.
DR InParanoid; Q1G3Y4; -.
DR OMA; VEHHETS; -.
DR OrthoDB; 1582126at2759; -.
DR PhylomeDB; Q1G3Y4; -.
DR PRO; PR:Q1G3Y4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0045839; P:negative regulation of mitotic nuclear division; IBA:GO_Central.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IEA:InterPro.
DR InterPro; IPR040389; SMR.
DR PANTHER; PTHR33142; PTHR33142; 1.
PE 3: Inferred from homology;
KW Cell cycle; Protein kinase inhibitor; Reference proteome.
FT CHAIN 1..106
FT /note="Cyclin-dependent protein kinase inhibitor SMR15"
FT /id="PRO_0000438474"
SQ SEQUENCE 106 AA; 11711 MW; 75DA8F558778F4DF CRC64;
MGFSGKTYHQ FDRKFSETTE GKKCVITGIS LHSTVKPISL SSSAVSNTED EDLCPTTPTA
DSVRIPTVIP CPPAPKKRKL TLKVSYGPRE FFSPPDLETV FIYRTT
