SMR2A_MOUSE
ID SMR2A_MOUSE Reviewed; 150 AA.
AC O09133;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Submaxillary gland androgen-regulated protein 2, isoform alpha;
DE AltName: Full=Salivary protein MSG2, isoform alpha;
DE Flags: Precursor;
GN Name=Smr2; Synonyms=Msg2, Vcs2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
RC STRAIN=BALB/cJ; TISSUE=Submandibular gland;
RX PubMed=8194749; DOI=10.1016/0378-1119(94)90258-5;
RA Tronik-Le Roux D., Senorale-Pose M., Rougeon F.;
RT "Three novel SMR1-related cDNAs characterized in the submaxillary gland of
RT mice show extensive evolutionary divergence in the protein coding region.";
RL Gene 142:175-182(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS ALPHA; BETA; GAMMA;
RP DELTA AND EPSILON).
RC STRAIN=BALB/cJ; TISSUE=Submandibular gland;
RX PubMed=9409774; DOI=10.1016/s0378-1119(97)00430-7;
RA Senorale-Pose M., Rougeon F.;
RT "The mouse Vcs2 gene is a composite structure which evolved by gene fusion
RT and encodes five distinct salivary mRNA species.";
RL Gene 201:75-85(1997).
CC -!- FUNCTION: May play a role in protection or detoxification.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=Alpha;
CC IsoId=O09133-1; Sequence=Displayed;
CC Name=Beta;
CC IsoId=O35982-1; Sequence=External;
CC Name=Gamma;
CC IsoId=O35985-1; Sequence=External;
CC Name=Delta;
CC IsoId=O35979-1; Sequence=External;
CC Name=Epsilon;
CC IsoId=O35961-1; Sequence=External;
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DR EMBL; U82380; AAB93420.1; -; mRNA.
DR EMBL; U82375; AAB93510.1; -; Genomic_DNA.
DR PIR; I48670; I48670.
DR AlphaFoldDB; O09133; -.
DR PRIDE; O09133; -.
DR ProteomicsDB; 261527; -. [O09133-1]
DR Ensembl; ENSMUST00000199635; ENSMUSP00000142444; ENSMUSG00000029281. [O09133-1]
DR MGI; MGI:102762; Smr2.
DR VEuPathDB; HostDB:ENSMUSG00000029281; -.
DR GeneTree; ENSGT00940000164646; -.
DR HOGENOM; CLU_150752_0_0_1; -.
DR PhylomeDB; O09133; -.
DR ChiTaRS; Smr2; mouse.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; O09133; protein.
DR Bgee; ENSMUSG00000029281; Expressed in triceps brachii and 131 other tissues.
DR ExpressionAtlas; O09133; differential.
DR Genevisible; O09133; MM.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; ISO:MGI.
DR GO; GO:0030414; F:peptidase inhibitor activity; ISO:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:MGI.
DR GO; GO:0010466; P:negative regulation of peptidase activity; ISO:MGI.
DR GO; GO:0051930; P:regulation of sensory perception of pain; ISO:MGI.
DR GO; GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW.
DR InterPro; IPR026288; SMR-like.
DR PANTHER; PTHR14179; PTHR14179; 1.
DR Pfam; PF15621; PROL5-SMR; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Detoxification; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..150
FT /note="Submaxillary gland androgen-regulated protein 2,
FT isoform alpha"
FT /id="PRO_0000022374"
SQ SEQUENCE 150 AA; 16630 MW; 61585A8262BF6550 CRC64;
MKALYMVFVL WVLIGCFLSG ECHRAPRGQH GPRRTLAPST HHRHYHLYPL PDPNHVQFGV
PPFLPTSSGF CKPHSLSLYA PPFEIVIQPS SIIVTIPGLI LTLSSDPSPQ RNCPARTPPR
VKANIIPGPI TAQLLPKLKI PLIILDDSRK
