ID   SMR2D_MOUSE             Reviewed;         143 AA.
AC   O35979; Q2NKH7;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Submaxillary gland androgen-regulated protein 2, isoform delta;
DE   AltName: Full=Salivary protein MSG2, isoform delta;
DE   Flags: Precursor;
GN   Name=Smr2; Synonyms=Msg2, Vcs2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS ALPHA; BETA; GAMMA;
RP   DELTA AND EPSILON).
RC   STRAIN=BALB/cJ; TISSUE=Submandibular gland;
RX   PubMed=9409774; DOI=10.1016/s0378-1119(97)00430-7;
RA   Senorale-Pose M., Rougeon F.;
RT   "The mouse Vcs2 gene is a composite structure which evolved by gene fusion
RT   and encodes five distinct salivary mRNA species.";
RL   Gene 201:75-85(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in protection or detoxification.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=Delta;
CC         IsoId=O35979-1; Sequence=Displayed;
CC       Name=Alpha;
CC         IsoId=O09133-1; Sequence=External;
CC       Name=Beta;
CC         IsoId=O35982-1; Sequence=External;
CC       Name=Gamma;
CC         IsoId=O35985-1; Sequence=External;
CC       Name=Epsilon;
CC         IsoId=O35961-1; Sequence=External;
CC   -!- MISCELLANEOUS: [Isoform Delta]: Produced by translation on another
CC       frame.
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DR   EMBL; U82378; AAB93516.1; -; mRNA.
DR   EMBL; U82375; AAB93513.1; -; Genomic_DNA.
DR   EMBL; BC111829; AAI11830.1; -; mRNA.
DR   CCDS; CCDS80321.1; -. [O35979-1]
DR   RefSeq; NP_001239608.1; NM_001252679.1. [O35979-1]
DR   RefSeq; NP_001239609.1; NM_001252680.1. [O35979-1]
DR   RefSeq; NP_001239610.1; NM_001252681.1. [O35979-1]
DR   AlphaFoldDB; O35979; -.
DR   PRIDE; O35979; -.
DR   DNASU; 20600; -.
DR   Ensembl; ENSMUST00000196070; ENSMUSP00000143443; ENSMUSG00000029281. [O35979-1]
DR   Ensembl; ENSMUST00000196477; ENSMUSP00000142688; ENSMUSG00000029281. [O35979-1]
DR   GeneID; 20600; -.
DR   KEGG; mmu:20600; -.
DR   UCSC; uc008xzm.1; mouse. [O35979-1]
DR   CTD; 20600; -.
DR   MGI; MGI:102762; Smr2.
DR   VEuPathDB; HostDB:ENSMUSG00000029281; -.
DR   GeneTree; ENSGT00940000164646; -.
DR   BioGRID-ORCS; 20600; 0 hits in 71 CRISPR screens.
DR   ChiTaRS; Smr2; mouse.
DR   Proteomes; UP000000589; Chromosome 5.
DR   Bgee; ENSMUSG00000029281; Expressed in triceps brachii and 131 other tissues.
DR   ExpressionAtlas; O35979; differential.
DR   Genevisible; O35979; MM.
DR   GO; GO:0005576; C:extracellular region; ISO:MGI.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; ISO:MGI.
DR   GO; GO:0030414; F:peptidase inhibitor activity; ISO:MGI.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:MGI.
DR   GO; GO:0010466; P:negative regulation of peptidase activity; ISO:MGI.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; ISO:MGI.
DR   GO; GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW.
DR   InterPro; IPR026288; SMR-like.
DR   PANTHER; PTHR14179; PTHR14179; 1.
DR   Pfam; PF15621; PROL5-SMR; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Detoxification; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..143
FT                   /note="Submaxillary gland androgen-regulated protein 2,
FT                   isoform delta"
FT                   /id="PRO_0000022377"
FT   REGION          28..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..143
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   143 AA;  15980 MW;  97DEEE04E59A9F5F CRC64;
     MKPLCLVFGL CVLIGCFLSS ECQRGFRGQH DPTRPLSPSN PSSHFYPQPD PNRVQISQPD
     NIPIFMFEQP HSLNICVPPP PLYLGEEFEK LPPNTHIPYI LIRPDIEPPS KYIQPVPRKK
     SNATPAANNF ITTATAPNST DSF