ID   SMR2E_MOUSE             Reviewed;          40 AA.
AC   O35961;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Submaxillary gland androgen-regulated protein 2, isoform epsilon;
DE   AltName: Full=Salivary protein MSG2, isoform epsilon;
DE   Flags: Precursor;
GN   Name=Smr2; Synonyms=Msg2, Vcs2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS ALPHA; BETA; GAMMA;
RP   DELTA AND EPSILON).
RC   STRAIN=BALB/cJ; TISSUE=Submandibular gland;
RX   PubMed=9409774; DOI=10.1016/s0378-1119(97)00430-7;
RA   Senorale-Pose M., Rougeon F.;
RT   "The mouse Vcs2 gene is a composite structure which evolved by gene fusion
RT   and encodes five distinct salivary mRNA species.";
RL   Gene 201:75-85(1997).
CC   -!- FUNCTION: May play a role in protection or detoxification.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=Epsilon;
CC         IsoId=O35961-1; Sequence=Displayed;
CC       Name=Alpha;
CC         IsoId=O09133-1; Sequence=External;
CC       Name=Beta;
CC         IsoId=O35982-1; Sequence=External;
CC       Name=Gamma;
CC         IsoId=O35985-1; Sequence=External;
CC       Name=Delta;
CC         IsoId=O35979-1; Sequence=External;
CC   -!- MISCELLANEOUS: [Isoform Epsilon]: May be produced at very low levels
CC       due to a premature stop codon in the mRNA, leading to nonsense-mediated
CC       mRNA decay.
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DR   EMBL; U82379; AAB93517.1; -; mRNA.
DR   EMBL; U82375; AAB93511.1; -; Genomic_DNA.
DR   AlphaFoldDB; O35961; -.
DR   SMR; O35961; -.
DR   PRIDE; O35961; -.
DR   MGI; MGI:102762; Smr2.
DR   ChiTaRS; Smr2; mouse.
DR   Proteomes; UP000000589; Unplaced.
DR   GO; GO:0005576; C:extracellular region; ISO:MGI.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; ISO:MGI.
DR   GO; GO:0030414; F:peptidase inhibitor activity; ISO:MGI.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:MGI.
DR   GO; GO:0010466; P:negative regulation of peptidase activity; ISO:MGI.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; ISO:MGI.
DR   GO; GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW.
DR   InterPro; IPR026288; SMR-like.
DR   Pfam; PF15621; PROL5-SMR; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Detoxification; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..40
FT                   /note="Submaxillary gland androgen-regulated protein 2,
FT                   isoform epsilon"
FT                   /id="PRO_0000022378"
SQ   SEQUENCE   40 AA;  4678 MW;  564D37D1F6302F9E CRC64;
     MKALYMVFVL WVLIGCFLRC KERMGSEEKQ AQEDPGDQDL