SMR3A_HUMAN
ID SMR3A_HUMAN Reviewed; 134 AA.
AC Q99954;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Submaxillary gland androgen-regulated protein 3A;
DE AltName: Full=Proline-rich protein 5;
DE AltName: Full=Proline-rich protein PBI;
DE Flags: Precursor;
GN Name=SMR3A; Synonyms=PBI, PROL5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-42 AND LEU-132.
RX PubMed=9354371; DOI=10.1093/oxfordjournals.jbchem.a021689;
RA Isemura S., Saitoh E.;
RT "Nucleotide sequence of gene PBI encoding a protein homologous to salivary
RT proline-rich protein P-B.";
RL J. Biochem. 121:1025-1030(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- FUNCTION: May play a role in protection or detoxification.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q99954; Q7Z4W3: KRTAP19-3; NbExp=3; IntAct=EBI-12067698, EBI-12020132;
CC Q99954; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-12067698, EBI-10261141;
CC Q99954; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-12067698, EBI-12040603;
CC Q99954; O00308: WWP2; NbExp=3; IntAct=EBI-12067698, EBI-743923;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PROL1/PROL3 family. {ECO:0000305}.
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DR EMBL; D89501; BAA13971.1; -; Genomic_DNA.
DR EMBL; AC106884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS34000.1; -.
DR PIR; JC5572; JC5572.
DR RefSeq; NP_036522.3; NM_012390.3.
DR RefSeq; XP_016863510.1; XM_017008021.1.
DR AlphaFoldDB; Q99954; -.
DR BioGRID; 117923; 8.
DR IntAct; Q99954; 6.
DR STRING; 9606.ENSP00000226460; -.
DR BioMuta; SMR3A; -.
DR DMDM; 296452907; -.
DR MassIVE; Q99954; -.
DR PaxDb; Q99954; -.
DR PeptideAtlas; Q99954; -.
DR PRIDE; Q99954; -.
DR Antibodypedia; 44321; 23 antibodies from 12 providers.
DR DNASU; 26952; -.
DR Ensembl; ENST00000226460.5; ENSP00000226460.4; ENSG00000109208.5.
DR GeneID; 26952; -.
DR KEGG; hsa:26952; -.
DR MANE-Select; ENST00000226460.5; ENSP00000226460.4; NM_012390.4; NP_036522.3.
DR UCSC; uc003hfg.2; human.
DR CTD; 26952; -.
DR DisGeNET; 26952; -.
DR GeneCards; SMR3A; -.
DR HGNC; HGNC:19216; SMR3A.
DR HPA; ENSG00000109208; Tissue enriched (salivary).
DR MIM; 618340; gene.
DR neXtProt; NX_Q99954; -.
DR OpenTargets; ENSG00000109208; -.
DR PharmGKB; PA38824; -.
DR VEuPathDB; HostDB:ENSG00000109208; -.
DR eggNOG; ENOG502TEGF; Eukaryota.
DR GeneTree; ENSGT00980000198815; -.
DR HOGENOM; CLU_156938_0_0_1; -.
DR InParanoid; Q99954; -.
DR OMA; ACFTPGK; -.
DR TreeFam; TF338396; -.
DR PathwayCommons; Q99954; -.
DR SignaLink; Q99954; -.
DR BioGRID-ORCS; 26952; 13 hits in 1043 CRISPR screens.
DR GenomeRNAi; 26952; -.
DR Pharos; Q99954; Tbio.
DR PRO; PR:Q99954; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q99954; protein.
DR Bgee; ENSG00000109208; Expressed in parotid gland and 15 other tissues.
DR Genevisible; Q99954; HS.
DR GO; GO:0005576; C:extracellular region; TAS:ProtInc.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0051930; P:regulation of sensory perception of pain; IBA:GO_Central.
DR InterPro; IPR026288; SMR-like.
DR PANTHER; PTHR14179; PTHR14179; 1.
DR Pfam; PF15621; PROL5-SMR; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..134
FT /note="Submaxillary gland androgen-regulated protein 3A"
FT /id="PRO_0000022116"
FT REGION 19..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..90
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..134
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 28
FT /note="G -> R (in dbSNP:rs10031844)"
FT /id="VAR_056989"
FT VARIANT 42
FT /note="C -> R (in dbSNP:rs10024123)"
FT /evidence="ECO:0000269|PubMed:9354371"
FT /id="VAR_060392"
FT VARIANT 132
FT /note="P -> L (in dbSNP:rs6853742)"
FT /evidence="ECO:0000269|PubMed:9354371"
FT /id="VAR_060393"
SQ SEQUENCE 134 AA; 14048 MW; BF0192C0D09C4A63 CRC64;
MKSLTWILGL WALAACFTPG ESQRGPRGPY PPGPLAPPPP PCFPFGTGFV PPPHPPPYGP
GRFPPPLSPP YGPGRIPPSP PPPYGPGRIQ SHSLPPPYGP GYPQPPSQPR PYPPGPPFFP
VNSPTDPALP TPAP
