SMR3A_MOUSE
ID SMR3A_MOUSE Reviewed; 147 AA.
AC Q61900; B7ZP11;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Submaxillary gland androgen-regulated protein 3A;
DE AltName: Full=Salivary protein MSG1;
DE AltName: Full=Submaxillary gland androgen-regulated protein 1;
DE Flags: Precursor;
GN Name=Smr3a; Synonyms=Msg1, Smr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Submandibular gland;
RX PubMed=8194749; DOI=10.1016/0378-1119(94)90258-5;
RA Tronik-Le Roux D., Senorale-Pose M., Rougeon F.;
RT "Three novel SMR1-related cDNAs characterized in the submaxillary gland of
RT mice show extensive evolutionary divergence in the protein coding region.";
RL Gene 142:175-182(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in protection or detoxification.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Secreted into saliva by submaxillary gland.
CC -!- SIMILARITY: Belongs to the PROL1/PROL3 family. {ECO:0000305}.
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DR EMBL; X71629; CAA50636.1; -; mRNA.
DR EMBL; BC031806; AAH31806.1; -; mRNA.
DR EMBL; BC031921; AAH31921.1; -; mRNA.
DR EMBL; BC034553; AAH34553.1; -; mRNA.
DR EMBL; BC055857; AAH55857.1; -; mRNA.
DR EMBL; BC141243; AAI41244.1; -; mRNA.
DR EMBL; BC145569; AAI45570.1; -; mRNA.
DR CCDS; CCDS19398.1; -.
DR PIR; I48669; S37485.
DR RefSeq; NP_035552.1; NM_011422.3.
DR RefSeq; XP_017176242.1; XM_017320753.1.
DR AlphaFoldDB; Q61900; -.
DR STRING; 10090.ENSMUSP00000031211; -.
DR PaxDb; Q61900; -.
DR PeptideAtlas; Q61900; -.
DR PRIDE; Q61900; -.
DR ProteomicsDB; 257276; -.
DR DNASU; 20599; -.
DR Ensembl; ENSMUST00000031211; ENSMUSP00000031211; ENSMUSG00000029280.
DR GeneID; 20599; -.
DR KEGG; mmu:20599; -.
DR UCSC; uc012dxy.1; mouse.
DR CTD; 26952; -.
DR MGI; MGI:102763; Smr3a.
DR VEuPathDB; HostDB:ENSMUSG00000029280; -.
DR GeneTree; ENSGT00860000135309; -.
DR HOGENOM; CLU_150752_0_0_1; -.
DR InParanoid; Q61900; -.
DR OMA; ACFTPGK; -.
DR OrthoDB; 1887836at2759; -.
DR TreeFam; TF338396; -.
DR BioGRID-ORCS; 20599; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Smr3a; mouse.
DR PRO; PR:Q61900; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q61900; protein.
DR Bgee; ENSMUSG00000029280; Expressed in esophagus and 6 other tissues.
DR ExpressionAtlas; Q61900; baseline and differential.
DR Genevisible; Q61900; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0051930; P:regulation of sensory perception of pain; IBA:GO_Central.
DR InterPro; IPR026288; SMR-like.
DR PANTHER; PTHR14179; PTHR14179; 1.
DR Pfam; PF15621; PROL5-SMR; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..147
FT /note="Submaxillary gland androgen-regulated protein 3A"
FT /id="PRO_0000022368"
FT REPEAT 43..54
FT /note="1"
FT REPEAT 55..66
FT /note="2"
FT REPEAT 67..78
FT /note="3"
FT REGION 27..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..78
FT /note="3 X 12 AA tandem repeats of G-P-G-I-G-R-P-[HP]-P-P-
FT P-[PF]"
FT COMPBIAS 32..105
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 147 AA; 15544 MW; 07D64E22F1BF58C2 CRC64;
MKPLNLVLGL CILVGCFLSC ECHRGPRRHD PRGPFPPPPP PHGPGIGRPH PPPFGPGIGR
PPPPPFGPGI GRPPPPPPCP PVPPHPRPPS NPSPPPTPSI PPTGPPTTVQ ATTMPAASIS
ITTPTARDST DIFWRLWELI NSLLQQE
